| Added by | adjiane.lab |
|---|---|
| Group name | EquipeAD |
| Item Type | Journal Article |
| Title | Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems? |
| Creator | Tissot et al. |
| Author | Tazzio Tissot |
| Author | Beata Ujvari |
| Author | Eric Solary |
| Author | Patrice Lassus |
| Author | Benjamin Roche |
| Author | Frédéric Thomas |
| Abstract | By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment. |
| Publication | Biochimica Et Biophysica Acta |
| Volume | 1865 |
| Issue | 2 |
| Pages | 147-154 |
| Date | Apr 2016 |
| Journal Abbr | Biochim. Biophys. Acta |
| Language | eng |
| DOI | 10.1016/j.bbcan.2016.01.005 |
| ISSN | 0006-3002 |
| Library Catalog | PubMed |
| Extra | PMID: 26845682 |
| Tags | cnrs, Disease Progression, Ecology, Ecosystem, Evolution, Humans, Mutation, Neoplasms, Non-cell-autonomous effects, original, Tumor Microenvironment |
| Date Added | 2019/05/14 - 12:07:53 |
| Date Modified | 2024/09/30 - 01:36:00 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
