| Added by | pcoopman |
|---|---|
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | Impact of body mass index on overall survival in patients with metastatic breast cancer |
| Creator | Saleh et al. |
| Author | Khalil Saleh |
| Author | Matthieu Carton |
| Author | Véronique Dieras |
| Author | Pierre-Etienne Heudel |
| Author | Etienne Brain |
| Author | Véronique D'Hondt |
| Author | Audrey Mailliez |
| Author | Anne Patsouris |
| Author | Marie-Ange Mouret-Reynier |
| Author | Anthony Goncalves |
| Author | Jean Marc Ferrero |
| Author | Thierry Petit |
| Author | George Emile |
| Author | Lionel Uwer |
| Author | Marc Debled |
| Author | Florence Dalenc |
| Author | Christelle Jouannaud |
| Author | Sylvain Ladoire |
| Author | Marianne Leheurteur |
| Author | Paul Cottu |
| Author | Lucie Veron |
| Author | Alexia Savignoni |
| Author | Coralie Courtinard |
| Author | Mathieu Robain |
| Author | Suzette Delaloge |
| Author | Elise Deluche |
| Abstract | BACKGROUND: High Body mass index (BMI) is a risk factor for breast cancer among postmenopausal women and an adverse prognostic factor in early-stage. Little is known about its impact on clinical outcomes in patients with metastatic breast cancer (MBC). METHODS: The National ESME-MBC observational cohort includes all consecutive patients newly diagnosed with MBC between Jan 2008 and Dec 2016 in the 18 French comprehensive cancer centers. RESULTS: Of 22 463 patients in ESME-MBC, 12 999 women had BMI data available at MBC diagnosis. Median BMI was 24.9 kg/m2 (range 12.1-66.5); 20% of women were obese and 5% underweight. Obesity was associated with more de novo MBC, while underweight patients had more aggressive cancer features. Median overall survival (OS) of the BMI cohort was 47.4 months (95% CI [46.2-48.5]) (median follow-up: 48.6 months). Underweight was independently associated with a worse OS (median OS 33 months; HR 1.14, 95%CI, 1.02-1.27) and first line progression-free survival (HR, 1.11; 95%CI, 1.01; 1.22), while overweight or obesity had no effect. CONCLUSION: Overweight and obesity are not associated with poorer outcomes in women with metastatic disease, while underweight appears as an independent adverse prognostic factor. |
| Publication | Breast (Edinburgh, Scotland) |
| Volume | 55 |
| Pages | 16-24 |
| Date | 2021-02 |
| Journal Abbr | Breast |
| Language | eng |
| DOI | 10.1016/j.breast.2020.11.014 |
| ISSN | 1532-3080 |
| Library Catalog | PubMed |
| Extra | PMID: 33307392 PMCID: PMC7725947 |
| Tags | BMI, Body Mass Index, Breast Neoplasms, clinic, Female, Humans, Obesity, Overweight, Prognosis, Retrospective Studies, Risk Factors, Underweight |
| Date Added | 2023/11/20 - 17:10:32 |
| Date Modified | 2023/11/20 - 17:13:02 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
