| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Helical tomotherapy and volumetric modulated arc therapy: New therapeutic arms in the breast cancer radiotherapy |
| Creator | Lauche et al. |
| Author | Olivier Lauche |
| Author | Youlia M. Kirova |
| Author | Pascal Fenoglietto |
| Author | Emilie Costa |
| Author | Claire Lemanski |
| Author | Olivier Riou |
| Author | David Tiberi |
| Author | Francois Campana |
| Author | Alain Fourquet |
| Author | David Azria |
| Abstract | AIM: To analyse clinical and dosimetric results of helical tomotherapy (HT) and volumetric modulated arc therapy (VMAT) in complex adjuvant breast and nodes irradiation. METHODS: Seventy-three patients were included (31 HT and 42 VMAT). Dose were 63.8 Gy (HT) and 63.2 Gy (VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes (SCN) and internal mammary chain (IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions. Margins to particle tracking velocimetry were greater in the VMAT cohort (7 mm vs 5 mm). RESULTS: For the HT cohort, the coverage of clinical target volumes was as follows: Tumour bed: 99.4% ± 2.4%; breast: 98.4% ± 4.3%; SCN: 99.5% ± 1.2%; IMC: 96.5% ± 13.9%. For the VMAT cohort, the coverage was as follows: Tumour bed: 99.7% ± 0.5%, breast: 99.3% ± 0.7%; SCN: 99.6% ± 1.4%; IMC: 99.3% ± 3%. For ipsilateral lung, Dmean and V20 were 13.6 ± 1.2 Gy, 21.1% ± 5% (HT) and 13.6 ± 1.4 Gy, 20.1% ± 3.2% (VMAT). Dmean and V30 of the heart were 7.4 ± 1.4 Gy, 1% ± 1% (HT) and 10.3 ± 4.2 Gy, 2.5% ± 3.9% (VMAT). For controlateral breast Dmean was 3.6 ± 0.2 Gy (HT) and 4.6 ± 0.9 Gy (VMAT). Acute skin toxicity grade 3 was 5% in the two cohorts. CONCLUSION: HT and VMAT in complex adjuvant breast irradiation allow a good coverage of target volumes with an acceptable acute tolerance. A longer follow-up is needed to assess the impact of low doses to healthy tissues. |
| Publication | World Journal of Radiology |
| Volume | 8 |
| Issue | 8 |
| Pages | 735-742 |
| Date | Aug 28, 2016 |
| Journal Abbr | World J Radiol |
| Language | eng |
| DOI | 10.4329/wjr.v8.i8.735 |
| ISSN | 1949-8470 |
| Short Title | Helical tomotherapy and volumetric modulated arc therapy |
| Library Catalog | PubMed |
| Extra | PMID: 27648167 PMCID: PMC5002504 |
| Tags | Breast cancer radiotherapy, clinic, Helical tomotherapy, Intensity modulated radiation therapy, Three-dimensional conformal radiotherapy, Toxicity, Volumetric modulated arc therapy |
| Date Added | 2019/05/28 - 22:05:28 |
| Date Modified | 2019/05/28 - 22:05:45 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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