| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Analysis of the StoRM cohort reveals physical activity to be associated with survival in metastatic breast cancer |
| Creator | Delrieu et al. |
| Author | Lidia Delrieu |
| Author | Emmanuelle Jacquet |
| Author | Céline Segura-Ferlay |
| Author | Ellen Blanc |
| Author | Olivia Febvey-Combes |
| Author | Christine Friedenreich |
| Author | Gilles Romieu |
| Author | William Jacot |
| Author | Maria Rios |
| Author | Pierre-Etienne Heudel |
| Author | Célia Roemer-Becuwe |
| Author | Christelle Jouannaud |
| Author | Olivier Tredan |
| Author | Monica Arnedos |
| Author | Hubert Orfeuvre |
| Author | Nathalie Quenel-Tueux |
| Author | Jean-Philippe Jacquin |
| Author | Jean-Marc Ferrero |
| Author | Isabelle Moullet |
| Author | Sophie Abadie-Lacourtoisie |
| Author | Frédérique Penault-Llorca |
| Author | David Cox |
| Author | Thomas Bachelot |
| Abstract | Benefits of physical activity are widely demonstrated for early stage cancers but few studies have focused on metastatic disease. The purpose of this study was to determine the impact of physical activity on survival in patients with metastatic breast cancer. We conducted a secondary analysis of the national, multicentric, non-randomized, prospective cohort SNPs to Risk of Metastasis (StoRM) study. The level of physical activity was self-reported at inclusion and divided into three categories of physical activity: light level, moderate level, and vigorous level. Overall, 833 patients (56.2%) completed the physical activity questionnaire at baseline on average physical activity during the previous year: 11.6% had a light level of physical activity, 69.0% achieved moderate levels of physical activity and 19.3% reported vigorous levels of physical activity. After adjustment for confounding, physical activity was not statistically significantly associated with overall survival in the whole population. Subgroup analysis identified that both vigorous and moderate physical activity were associated with statistically significantly improved overall survival compared to light physical activity level only in the HER2 positive subgroup (HR 0.23; 95% CI 0.07-0.70, p?=?0.01 and HR 0.38; 95% CI 0.15-0.96, p?=?0.04). Physical activity done during the previous year was associated with survival in HER2 positive metastatic breast cancer patients. These results suggest that overall survival in metastatic breast cancer patients could be improved through physical activity which should be considered as a complementary intervention for these individuals. The study showed that moderate/vigorous levels of physical activity were associated with better overall survival, and that these associations remained statistically significant in multivariate analysis in the HER2 positive subgroup. These results have clinical relevance and justify the recommendations for physical activity interventions in metastatic breast cancer. |
| Publication | Scientific Reports |
| Volume | 10 |
| Issue | 1 |
| Pages | 10757 |
| Date | 2020-07-01 |
| Journal Abbr | Sci Rep |
| Language | eng |
| DOI | 10.1038/s41598-020-67431-6 |
| ISSN | 2045-2322 |
| Library Catalog | PubMed |
| Extra | PMID: 32612272 PMCID: PMC7329808 |
| Tags | Aged, Anthropometry, Body Mass Index, Breast Neoplasms, clinic, Data Interpretation, Statistical, Exercise, Female, Humans, Middle Aged, Multivariate Analysis, Neoplasm Metastasis, Polymorphism, Single Nucleotide, Prognosis, Proportional Hazards Models, Prospective Studies, Receptor, ErbB-2, Surveys and Questionnaires, Survival Rate, Treatment Outcome, Triple Negative Breast Neoplasms |
| Date Added | 2023/11/14 - 15:27:47 |
| Date Modified | 2023/11/14 - 15:38:19 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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