| Added by | mollevi |
|---|---|
| Last modified by | celine.gongora |
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | [Tasquinimod: How to act on microenvironment in metastatic prostate cancer] |
| Creator | Houede and Irani |
| Author | N. Houede |
| Author | J. Irani |
| Abstract | Despite the recent introduction of new drugs, castration-resistant metastatic prostate cancer, (mCRPC) remains a poor prognosis disease, with a crucial need for new therapeutic approaches. Tasquinimod is a newly developed molecule, orally administered, currently evaluated in phase III studies. Tasquinimod targets the tumor microenvironment, focusing on the angiogenic and immune components. Its specific action on the S100A9 protein restores immunity and reduces angiogenesis. A phase II double-blind randomized study against placebo showed an improvement of more than 50% of progression free survival in the group of mCRPC patients treated with tasquinimod, as compared to the placebo group. At a dose of 1mg/day, the tolerance of tasquinimod appeared acceptable. This review presents the available preclinical and clinical results of tasquinimod, with a particular focus on the originality of its mode of action. |
| Publication | Prog Urol |
| Volume | 25 |
| Pages | 298-305 |
| Date | May 2015 |
| Journal Abbr | Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie |
| DOI | 10.1016/j.purol.2015.01.008 |
| ISSN | 1166-7087 (Print) 1166-7087 (Linking) |
| Tags | first, review |
| Date Added | 2018/07/20 - 10:05:58 |
| Date Modified | 2019/10/24 - 16:15:47 |
| Notes and Attachments | (Note) (Note) 25684391 (Attachment) |
Institut de Recherche en Cancérologie de
