| Added by | mollevi |
|---|---|
| Last modified by | André Pèlegrin |
| Group name | EquipeAP |
| Item Type | Journal Article |
| Title | Early onset breast cancer: differences in risk factors, tumor phenotype, and genotype between North African and South European women |
| Creator | Corsini et al. |
| Author | C. Corsini |
| Author | S. Henouda |
| Author | D. B. Nejima |
| Author | H. Bertet |
| Author | A. Toledano |
| Author | H. Boussen |
| Author | F. Habib |
| Author | A. Mouhout |
| Author | A. Gaballah |
| Author | H. E. Ghazaly |
| Author | C. Bourgier |
| Author | I. Coupier |
| Author | V. Galibert |
| Author | K. Baudry |
| Author | P. Vilquin |
| Author | L. Biquard |
| Author | J. M. Rey |
| Author | Y. Belkacemi |
| Author | P. Ihout |
| Author | D. Khayat |
| Author | M. C. Picot |
| Author | A. Bensalem |
| Author | P. Pujol |
| Abstract | PURPOSE: This report compares the risk factors, the tumor phenotypes, and the BRCA1/BRCA2 genotype of early onset breast cancer (EOBC) patients between Southern Europe and North Africa. METHODS: Four hundred and fifty six women with invasive EOBC ( 20%) tumors. There was a lower rate of BRCA1 mutation in North Africa (7 vs. 15%, P = 0.02). Three putative BRCA1/2 founder mutations were identified in North Africa. CONCLUSIONS: In EOBC, we found significant differences in risk factors, phenotype and a higher incidence of BRCA1 mutations in Southern Europe as compared to North Africa. The worst prognosis previously reported for EOBC in North Africa is more likely due to a higher stage at diagnosis than to a more aggressive phenotype, since triple negative tumors are more common in Southern Europe and advanced tumors in North Africa. |
| Publication | Breast Cancer Res Treat |
| Date | Aug 05 2017 |
| Journal Abbr | Breast cancer research and treatment |
| DOI | 10.1007/s10549-017-4434-y |
| ISSN | 1573-7217 (Electronic) 0167-6806 (Linking) |
| Tags | Africa, Northern, Age of Onset, BRCA1, BRCA1 Protein, BRCA2, BRCA2 Protein, Breast Neoplasms, clinic, collaboration, Early onset breast cancer, Female, France, Genotype, Humans, Neoplasm Staging, nonvisible, North Africa, original, Phenotype, Prospective Studies, Risk Factors |
| Date Added | 2018/07/20 - 10:01:50 |
| Date Modified | 2019/12/11 - 18:26:13 |
| Notes and Attachments | (Note) (Note) 28779219 (Attachment) |
Institut de Recherche en Cancérologie de
