| Added by | Cavailles |
|---|---|
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | Non-achievement of LDL-cholesterol targets in patients with diabetes at very-high cardiovascular risk receiving statin treatment: Incidence and risk factors |
| Creator | Breuker et al. |
| Author | Cyril Breuker |
| Author | Florian Clement |
| Author | Thibault Mura |
| Author | Valérie Macioce |
| Author | Audrey Castet-Nicolas |
| Author | Yohan Audurier |
| Author | Catherine Boegner |
| Author | Emilie Morcrette |
| Author | Anne Jalabert |
| Author | Maxime Villiet |
| Author | Antoine Avignon |
| Author | Ariane Sultan |
| Abstract | BACKGROUND: Cardiovascular diseases are the first cause of mortality in patients with diabetes, and LDL-cholesterol is a well-established cardiovascular risk factor. This study aimed to assess rate of LDL-cholesterol target attainment among patients with diabetes at very-high cardiovascular risk treated with statins, and to identify predictive factors of non-attainment of target in this population. METHODS: Patients were recruited in the Nutrition-Diabetes unit of Montpellier University Hospital, France, from 2014 to 2017. We included all consecutive patients with type 1 or type 2 diabetes receiving statin treatment and at very-high cardiovascular risk according to 2016 ESC guidelines, therefore having a LDL-cholesterol target of <1.8?mmol/L. LDL-cholesterol levels were measured upon admission. Variables independently associated with non-attainment of LDL-Cholesterol target were assessed using multivariable logistic regression. RESULTS: 654 patients were included. Mean age was 63.8?years (SD 11.0), 41.9% were women and 42.3% had a history of cardiovascular disease. 59% of patients did not achieve LDL-cholesterol target, with a median value (interquartile range) of 2.4?mmol/L (2.1-2.9) versus 1.4?mmol/L (1.1-1.6) in patients at target. Risk of non-attainment of LDL-cholesterol target value was increased in women (odds ratio [95% confidence interval]: 2.27 [1.62-3.17]) and decreased in patients with history of coronary artery disease (0.64 [0.45-0.89]) or history of stroke or transient ischemic attack (0.59 [0.33-1.07]). CONCLUSIONS: Management of dyslipidemia is suboptimal, even in very-high risk patients with diabetes under statins. Lipid-lowering treatment should be intensified, in particular in very high risk patients with diabetes who are women or in primary cardiovascular prevention. Clinical Trial number: NCT03449784. |
| Publication | International Journal of Cardiology |
| Volume | 268 |
| Pages | 195-199 |
| Date | Oct 01, 2018 |
| Journal Abbr | Int. J. Cardiol. |
| Language | eng |
| DOI | 10.1016/j.ijcard.2018.04.068 |
| ISSN | 1874-1754 |
| Short Title | Non-achievement of LDL-cholesterol targets in patients with diabetes at very-high cardiovascular risk receiving statin treatment |
| Library Catalog | PubMed |
| Extra | PMID: 30041785 |
| Tags | Aged, Biomarkers, Cardiovascular Diseases, Cardiovascular risk, Cholesterol, LDL, clinic, Diabetes Mellitus, Female, France, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Incidence, Lipid-lowering therapy, Low-density lipoprotein cholesterol, Male, Middle Aged, Risk Factors, Treatment Outcome, Type 2 diabetes |
| Date Added | 2019/05/16 - 10:09:31 |
| Date Modified | 2021/09/01 - 16:52:04 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) |
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