| Added by | mollevi |
|---|---|
| Last modified by | llasorsa |
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure |
| Creator | Thierry and Roch |
| Author | Alain R. Thierry |
| Abstract | We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given the rapid evolution of this disease's symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. This work allows us to propose new strategies for treating the pandemic. |
| Publication | Clinical Science (London, England: 1979) |
| Volume | 134 |
| Issue | 12 |
| Pages | 1295-1300 |
| Date | 06 26, 2020 |
| Journal Abbr | Clin. Sci. |
| Language | eng |
| DOI | 10.1042/CS20200531 |
| ISSN | 1470-8736 |
| Library Catalog | PubMed |
| Extra | PMID: 32543703 |
| Tags | Humans, Immunity, Innate, Multiple Organ Failure, Pandemics, pathogenesis, Pneumonia, Viral, Traps |
| Date Added | 2020/07/24 - 16:12:05 |
| Date Modified | 2025/01/10 - 15:36:43 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) Texte intégral (Attachment) |
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