| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease |
| Creator | Dietz et al. |
| Author | Matthieu Dietz |
| Author | Christel H. Kamani |
| Author | Emmanuel Deshayes |
| Author | Vincent Dunet |
| Author | Periklis Mitsakis |
| Author | George Coukos |
| Author | Marie Nicod Lalonde |
| Author | Niklaus Schaefer |
| Author | John O. Prior |
| Abstract | Abstract Background Integrin alpha-V-beta-3 (?v?3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of 68 Ga-NODAGA-RGD, a specific ? v ? 3 integrin ligand for PET. Materials and methods The data of 44 patients who underwent 68 Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed semi-quantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with clinically documented atherosclerotic cardiovascular disease, cardiovascular risk factors and calcified plaque burden. Data were compared using the Mann - Whitney U test, Pearson correlation and Spearman correlation. Results 68 Ga-NODAGA-RGD arterial uptake was significantly higher in patients with previous clinically documented atherosclerotic cardiovascular disease (mean TBR 2.44 [2.03 - 2.55] vs. 1.81 [1.56 - 1.96], p ?=?0.001) and showed a significant correlation with prior cardiovascular or cerebrovascular event ( r ?=?0.33, p ?=?0.027), BMI ( ? ?=?0.38, p ?=?0.01), plaque burden ( ? ?=?0.31, p ?=?0.04) and hypercholesterolemia ( r ?=?0.31, p ?=?0.04). Conclusions 68 Ga-NODAGA-RGD holds promise as a non-invasive marker of disease activity in atherosclerosis, providing information about intraplaque angiogenesis. |
| Publication | EJNMMI Research |
| Volume | 11 |
| Issue | 1 |
| Pages | 71 |
| Date | 12/2021 |
| Journal Abbr | EJNMMI Res |
| Language | en |
| DOI | 10.1186/s13550-021-00815-5 |
| ISSN | 2191-219X |
| Short Title | Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT |
| URL | https://ejnmmires.springeropen.com/articles/10.1186/s13550-021-00815-5 |
| Accessed | 2023/11/23 - 12:19:39 |
| Library Catalog | DOI.org (Crossref) |
| Extra | Number: 1 |
| Tags | 68Ga-NODAGA-RGD, Atherosclerosis, clinic, PET/CT |
| Date Added | 2023/11/23 - 12:44:39 |
| Date Modified | 2024/12/15 - 11:25:10 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) Texte intégral (Attachment) |
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