| Added by | celine.gongora |
|---|---|
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | Cabozantinib-nivolumab sequence in metastatic renal cell carcinoma: The CABIR study |
| Creator | Vano et al. |
| Author | Yann-Alexandre Vano |
| Author | Letuan Phan |
| Author | Gwenaelle Gravis |
| Author | Friederike Schlürmann |
| Author | Denis Maillet |
| Author | Mostefa Bennamoun |
| Author | Delphine Topart |
| Author | Delphine Borchiellini |
| Author | Raffaele Ratta |
| Author | Thomas Ryckewaert |
| Author | Ali Hasbini |
| Author | Sophie Hans |
| Author | Sheik Emambux |
| Author | Sandra Cournier |
| Author | Elena Braychenko |
| Author | Réza-Thierry Elaidi |
| Author | Stéphane Oudard |
| Abstract | Nivolumab and cabozantinib are approved agents in mRCC patients after sunitinib/pazopanib (TKI) failure. However, the optimal sequence, cabozantinib then nivolumab (CN) or nivolumab then cabozantinib (NC), is still unknown. The CABIR study aimed to identify the optimal sequence between CN and NC after frontline VEGFR-TKI. In this multicenter retrospective study, we collected data from mRCC pts receiving CN or NC, after frontline VEGFR-TKI. A propensity score (PrS) was calculated to manage bias selection, and sequence comparisons were carried out with a cox model on a matched sample 1:1. The primary endpoint was progression-free survival (PFS) from the start of second line to progression in third line (PFS2-3 ). Key secondary endpoints included overall survival from second line (OS2 ). Out of 139 included mRCC patients, 38 (27%) and 101 (73%) received CN and NC, respectively. Overlap in PrS allowed 1:1 matching for each CN pts, with characteristics well balanced. For both PFS2-3 and OS2 , NC sequence was superior to CN (PFS2-3 : HR = 0.58 [0.34-0.98], P = .043; OS2 : 0.66 [0.42-1.05], P = .080). Superior PFS2-3 was in patients treated between 6 and 18?months with prior VEGFR-TKI (P = .019) and was driven by a higher PFSL3 with cabozantinib when given after nivolumab (P? |
| Publication | International Journal of Cancer |
| Volume | 151 |
| Issue | 8 |
| Pages | 1335-1344 |
| Date | 2022-10-15 |
| Journal Abbr | Int J Cancer |
| Language | eng |
| DOI | 10.1002/ijc.34126 |
| ISSN | 1097-0215 |
| Short Title | Cabozantinib-nivolumab sequence in metastatic renal cell carcinoma |
| Library Catalog | PubMed |
| Extra | PMID: 35603906 |
| Tags | Anilides, Antineoplastic Agents, cabozantinib, Carcinoma, Renal Cell, clinic, Humans, Kidney Neoplasms, matching-adjusted study, Nivolumab, Protein Kinase Inhibitors, Pyridines, Retrospective Studies |
| Date Added | 2022/08/29 - 15:30:55 |
| Date Modified | 2022/08/29 - 16:43:24 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
