| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Integrating respiratory-gated PET-based target volume delineation in liver SBRT planning, a pilot study |
| Creator | Riou et al. |
| Author | Olivier Riou |
| Author | Benjamin Serrano |
| Author | David Azria |
| Author | Benoit Paulmier |
| Author | Remy Villeneuve |
| Author | Pascal Fenoglietto |
| Author | Antonella Artenie |
| Author | Cécile Ortholan |
| Author | Marc Faraggi |
| Author | Juliette Thariat |
| Abstract | BACKGROUND: To assess the feasibility and benefit of integrating four-dimensional (4D) Positron Emission Tomography (PET) - computed tomography (CT) for liver stereotactic body radiation therapy (SBRT) planning. METHODS: 8 patients with 14 metastases were accrued in the study. They all underwent a non-gated PET and a 4D PET centered on the liver. The same CT scan was used for attenuation correction, registration, and considered the planning CT for SBRT planning. Six PET phases were reconstructed for each 4D PET. By applying an individualized threshold to the 4D PET, a Biological Internal Target Volume (BITV) was generated for each lesion. A gated Planning Target Volume (PTVg) was created by adding 3 mm to account for set-up margins. This volume was compared to a manual Planning Target Volume (PTV) delineated with the help of a semi-automatic Biological Target Volume (BTV) obtained from the non-gated exam. A 5 mm radial and a 10 mm craniocaudal margins were applied to account for tumor motion and set-up margins to create the PTV. RESULTS: One undiagnosed liver metastasis was discovered thanks to the 4D PET. The semi-automatic BTV were significantly smaller than the BITV (p?=?0.0031). However, after applying adapted margins, 4D PET allowed a statistically significant decrease in the PTVg as compared to the PTV (p?=?0.0052). CONCLUSIONS: In comparison to non-gated PET, 4D PET may better define the respiratory movements of liver targets and improve SBRT planning for liver metastases. Furthermore, non respiratory-gated PET exams can both misdiagnose liver metastases and underestimate the real internal target volumes. |
| Publication | Radiation Oncology (London, England) |
| Volume | 9 |
| Pages | 127 |
| Date | Jun 02, 2014 |
| Journal Abbr | Radiat Oncol |
| Language | eng |
| DOI | 10.1186/1748-717X-9-127 |
| ISSN | 1748-717X |
| Library Catalog | PubMed |
| Extra | PMID: 24885897 PMCID: PMC4050417 |
| Tags | Aged, clinic, Female, first-last-corresponding, Follow-Up Studies, Humans, Imaging, Three-Dimensional, Liver Neoplasms, Male, Middle Aged, Neoplasm Staging, Neoplasms, Phantoms, Imaging, Pilot Projects, Positron-Emission Tomography, Prognosis, Prospective Studies, Radiosurgery, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Intensity-Modulated, Respiratory-Gated Imaging Techniques, Tomography, X-Ray Computed, Tumor Burden |
| Date Added | 2019/05/28 - 22:12:38 |
| Date Modified | 2019/05/28 - 22:13:00 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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