| Added by | mollevi |
|---|---|
| Last modified by | celine.gongora |
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | Clinical benefits of non-taxane chemotherapies in unselected patients with symptomatic metastatic castration-resistant prostate cancer after docetaxel: the GETUG-P02 study |
| Creator | Joly et al. |
| Author | F. Joly |
| Author | R. Delva |
| Author | L. Mourey |
| Author | E. Sevin |
| Author | E. Bompas |
| Author | L. Vedrine |
| Author | A. Ravaud |
| Author | J. C. Eymard |
| Author | N. Tubiana-Mathieu |
| Author | C. Linassier |
| Author | N. Houede |
| Author | A. Guillot |
| Author | F. Ringensen |
| Author | O. Cojocarasu |
| Author | B. Valenza |
| Author | A. Leconte |
| Author | S. Lheureux |
| Author | B. Clarisse |
| Author | S. Oudard |
| Abstract | OBJECTIVE: To evaluate the overall benefits of non-taxane chemotherapies in a non-selected population including unfit patients presenting with symptoms and pain. PATIENTS AND METHODS: This randomized phase II study reports data from 92 patients (52% >70 years old; 40% with a performance score of 2) previously treated with taxane-based chemotherapy, collected from 15 centres in France. Patients received i.v. mitoxantrone (MTX), oral vinorelbine, or oral etoposide, together with oral prednisone. Palliative benefit (pain response without progression of the disease), biological and tumoural responses, and toxicity profile as well as geriatric assessment (in elderly population) were analysed on an intention-to-treat basis. RESULTS: The palliative response rate was 17% for the whole population, and reached 29% when considering the MTX arm. Pain control was achieved in 40% of the patients. The median overall survival was 10.4 months, and was longer in palliative responders. Few grade 3-4 toxicities were observed. The subgroup analysis of elderly patients showed similar results regarding the number and dose intensity of treatments, efficacy and safety. CONCLUSION: In a population including frail and/or elderly patients, who are poorly represented in most clinical studies, non-taxane chemotherapy may remain a relevant option for metastatic prostate cancer having relapsed after a docetaxel-based regimen. Although new treatment options are now approved, the decision-making process should take into account their expected benefit/risk ratio based on the patient status. |
| Publication | BJU Int |
| Volume | 115 |
| Pages | 65-73 |
| Date | Jan 2015 |
| Journal Abbr | BJU international |
| DOI | 10.1111/bju.12552 |
| ISSN | 1464-410X (Electronic) 1464-4096 (Linking) |
| Tags | Age Factors, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use, Baxter, clinic, Etoposide/administration & dosage/adverse effects, Humans, Male, Middle Aged, Mitoxantrone/administration & dosage/adverse effects, Neoplasm Metastasis, Palliative Care, Pierre Fabre, Prednisone/administration & dosage/adverse effects, Prostatic Neoplasms, Castration-Resistant/*drug therapy/pathology, Taxoids/administration & dosage/adverse effects, Vinblastine/administration & dosage/adverse effects/analogs & derivatives |
| Date Added | 2018/07/20 - 10:05:58 |
| Date Modified | 2019/10/24 - 16:29:12 |
| Notes and Attachments | (Note) (Note) 24180479 (Attachment) |
Institut de Recherche en Cancérologie de
