| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Poorly cohesive cells gastric carcinoma including signet-ring cell cancer: Updated review of definition, classification and therapeutic management |
| Creator | Drubay et al. |
| Author | Vincent Drubay |
| Author | Frederiek Nuytens |
| Author | Florence Renaud |
| Author | Antoine Adenis |
| Author | Clarisse Eveno |
| Author | Guillaume Piessen |
| Abstract | While the incidence of gastric cancer (GC) in general has decreased worldwide in recent decades, the incidence of diffuse cancer historically comprising poorly cohesive cells-GC (PCC-GC) and including signet ring cell cancer is rising. Literature concerning PCC-GC is scarce and unclear, mostly due to a large variety of historically used definitions and classifications. Compared to other histological subtypes of GC, PCC-GC is nevertheless characterized by a distinct set of epidemiological, histological and clinical features which require a specific diagnostic and therapeutic approach. The aim of this review was to provide an update on the definition, classification and therapeutic strategies of PCC-GC. We focus on the updated histological definition of PCC-GC, along with its implications on future treatment strategies and study design. Also, specific considerations in the diagnostic management are discussed. Finally, the impact of some recent developments in the therapeutic management of GC in general such as the recently validated taxane-based regimens (5-Fluorouracil, leucovorin, oxaliplatin and docetaxel), the use of hyperthermic intraperitoneal chemotherapy as well as pressurized intraperitoneal aerosol chemotherapy and targeted therapy have been reviewed in depth for their relative importance for PCC-GC in particular. |
| Publication | World Journal of Gastrointestinal Oncology |
| Volume | 14 |
| Issue | 8 |
| Pages | 1406-1428 |
| Date | 2022-08-15 |
| Journal Abbr | World J Gastrointest Oncol |
| Language | eng |
| DOI | 10.4251/wjgo.v14.i8.1406 |
| ISSN | 1948-5204 |
| Short Title | Poorly cohesive cells gastric carcinoma including signet-ring cell cancer |
| Library Catalog | PubMed |
| Extra | PMID: 36160745 PMCID: PMC9412924 |
| Tags | Classification, Definition, Poorly cohesive cells gastric carcinoma, Therapeutic management |
| Date Added | 2022/09/29 - 15:03:39 |
| Date Modified | 2024/10/10 - 16:52:16 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
