| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions? |
| Creator | Guiu et al. |
| Author | Séverine Guiu |
| Author | Anita Wolfer |
| Author | William Jacot |
| Author | Pierre Fumoleau |
| Author | Gilles Romieu |
| Author | Franck Bonnetain |
| Author | Maryse Fiche |
| Abstract | The WHO classification of breast tumors distinguishes, besides invasive breast cancer 'of no special type' (former invasive ductal carcinoma, representing 60-70% of all breast cancers), 30 special types, of which invasive lobular carcinoma (ILC) is the most common (5-15%). We review the literature on (i) the specificity and heterogeneity of ILC biology as documented by various analytical techniques, including the results of molecular testing for risk of recurrence; (ii) the impact of lobular histology on prediction of prognosis and effect of systemic therapies in patients. Though it is generally admitted that ILC has a better prognosis than IDC, is endocrine responsive, and responds poorly to chemotherapy, currently available data do not unanimously support these assumptions. This review demonstrates some lack of specific data and a need for improving clinical research design to allow oncologists to make informed systemic therapy decisions in patients with ILC. Importantly, future studies should compare various endpoints in ILC breast cancer patients among the group of hormonosensitive breast cancer. |
| Publication | Critical Reviews in Oncology/Hematology |
| Volume | 92 |
| Issue | 3 |
| Pages | 235-257 |
| Date | Dec 2014 |
| Journal Abbr | Crit. Rev. Oncol. Hematol. |
| Language | eng |
| DOI | 10.1016/j.critrevonc.2014.07.003 |
| ISSN | 1879-0461 |
| Short Title | Invasive lobular breast cancer and its variants |
| Library Catalog | PubMed |
| Extra | PMID: 25129506 |
| Tags | Breast Neoplasms, Carcinoma, Lobular, Female, Genetic Testing, Genomics, Humans, Invasive breast cancer, Invasive lobular carcinoma, Luminal breast cancer, Neoplasm Grading, Neoplasm Invasiveness, Pleomorphic invasive lobular carcinoma, Predictive factor, Prognosis, review, Treatment Outcome, Tubulo-lobular carcinoma |
| Date Added | 2019/05/31 - 16:04:04 |
| Date Modified | 2019/05/31 - 16:04:21 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
