| Added by | mollevi |
|---|---|
| Last modified by | celine.gongora |
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | LINE-1 as a therapeutic target for castration-resistant prostate cancer |
| Creator | Houede et al. |
| Author | Pier Vincenzo Piazza |
| Author | Philippe Pourquier |
| Abstract | Prostate cancer is the third leading cause of death by cancer in men. Surgery or hormone deprivation usually contains the progression of the local forms of the disease. In metastatic situations, chemotherapy or second generation hormone therapies are used with an overall survival that never exceeds 36 months when tumors become resistant to castration. In the search for new alternatives, clinical trials with various classes of anticancer drugs have been performed, including chemotherapies, targeted therapies with kinase inhibitors, radium-223, or immunotherapies with somehow limited efficacy. Targeting LINE-1 with reverse transcriptase inhibitors was also proposed as an attractive strategy as retrotransposons may play a role in the initiation and the progression of prostate cancers. After reviewing the biological rational to use RT inhibitors in the treatment of prostate cancers, we will discuss the results of the phase II trial evaluating the efficacy of Efavirenz in the treatment of castration-resistant prostate cancers with a particular emphasis on pharmacokinetics data that were obtained. We will also discuss the positioning of other RT inhibitors in the current therapeutic armamentarium. |
| Publication | Frontiers in Bioscience (Landmark Edition) |
| Volume | 23 |
| Pages | 1292-1309 |
| Date | Jan 01, 2018 |
| Journal Abbr | Front Biosci (Landmark Ed) |
| Language | eng |
| ISSN | 1093-4715 |
| Library Catalog | PubMed |
| Extra | PMID: 28930600 |
| Tags | Benzoxazines, Clinical Trials, Phase II as Topic, first, Gene Expression Regulation, Neoplastic, Humans, last, Long Interspersed Nucleotide Elements, Male, Prostatic Neoplasms, Castration-Resistant, Reverse Transcriptase Inhibitors, review, Treatment Outcome |
| Date Added | 2018/09/14 - 16:39:03 |
| Date Modified | 2019/10/24 - 16:25:20 |
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