| Added by | mollevi |
|---|---|
| Last modified by | Nathalie Bonnefoy |
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Tumor antigen-targeting monoclonal antibody-based immunotherapy: Orchestrating combined strategies for the development of long-term antitumor immunity |
| Creator | Michaud et al. |
| Author | H. A. Michaud |
| Author | J. F. Eliaou |
| Author | V. Lafont |
| Author | N. Bonnefoy |
| Author | L. Gros |
| Abstract | Tumor antigen (TA)-targeting monoclonal antibody (mAb)-based treatments are considered to be one of the most successful strategies in cancer therapy. Besides targeting TAs and inducing tumor cell death, such antibodies interact with immune cells through Fc-dependent mechanisms to induce adaptive memory immune responses. However, multiple inhibitory/immunosuppressive pathways can be induced by tumor cells to limit the establishment of an efficient antitumor response and consequently a sustained clinical response to TA-targeting mAbs. Here, we provide an overview on how TA-targeting mAbs in combination with conventional cancer therapies and/or inhibitors of key immunosuppressive pathways might represent promising approaches to achieve long-term tumor control. |
| Publication | Oncoimmunology |
| Volume | 3 |
| Pages | e955684 |
| Date | Oct 2014 |
| Journal Abbr | Oncoimmunology |
| DOI | 10.4161/21624011.2014.955684 |
| ISSN | 2162-4011 (Print) 2162-4011 (Linking) |
| Tags | first-last-corresponding, review |
| Date Added | 2018/11/14 - 12:04:32 |
| Date Modified | 2019/05/28 - 21:51:58 |
| Notes and Attachments | (Note) (Note) 25941618 (Attachment) |
Institut de Recherche en Cancérologie de
