| Added by | mollevi |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Association between CT-texture-derived tumor heterogeneity, outcomes, and BRCA mutation status in patients with high-grade serous ovarian cancer |
| Creator | Meier et al. |
| Author | Andreas Meier |
| Author | Harini Veeraraghavan |
| Author | Stephanie Nougaret |
| Author | Yulia Lakhman |
| Author | Ramon Sosa |
| Author | Robert A. Soslow |
| Author | Elizabeth J. Sutton |
| Author | Hedvig Hricak |
| Author | Evis Sala |
| Author | Hebert A. Vargas |
| Abstract | PURPOSE: To assess the associations between inter-site texture heterogeneity parameters derived from computed tomography (CT), survival, and BRCA mutation status in women with high-grade serous ovarian cancer (HGSOC). MATERIALS AND METHODS: Retrospective study of 88 HGSOC patients undergoing CT and BRCA mutation status testing prior to primary cytoreductive surgery. Associations between texture metrics-namely inter-site cluster variance (SCV), inter-site cluster prominence (SCP), inter-site cluster entropy (SE)-and overall survival (OS), progression-free survival (PFS) as well as BRCA mutation status were assessed. RESULTS: Higher inter-site cluster variance (SCV) was associated with lower PFS (p?=?0.006) and OS (p?=?0.003). Higher inter-site cluster prominence (SCP) was associated with lower PFS (p?=?0.02) and higher inter-site cluster entropy (SE) correlated with lower OS (p?=?0.01). Higher values of all three metrics were significantly associated with lower complete surgical resection status in BRCA-negative patients (SE p?=?0.039, SCV p?=?0.006, SCP p?=?0.02), but not in BRCA-positive patients (SE p?=?0.7, SCV p?=?0.91, SCP p?=?0.67). None of the metrics were able to distinguish between BRCA mutation carrier and non-mutation carrier. CONCLUSION: The assessment of tumoral heterogeneity in the era of personalized medicine is important, as increased heterogeneity has been associated with distinct genomic abnormalities and worse patient outcomes. A radiomics approach using standard-of-care CT scans might have a clinical impact by offering a non-invasive tool to predict outcome and therefore improving treatment effectiveness. However, it was not able to assess BRCA mutation status in women with HGSOC. |
| Publication | Abdominal Radiology (New York) |
| Volume | 44 |
| Issue | 6 |
| Pages | 2040-2047 |
| Date | 06 2019 |
| Journal Abbr | Abdom Radiol (NY) |
| Language | eng |
| DOI | 10.1007/s00261-018-1840-5 |
| ISSN | 2366-0058 |
| Library Catalog | PubMed |
| Extra | PMID: 30474722 |
| Tags | Adult, Aged, Aged, 80 and over, BRCA mutation status, Cystadenocarcinoma, Serous, Female, Humans, Middle Aged, Mutation, Neoplasm Grading, Ovarian Neoplasms, Radiographic Image Interpretation, Computer-Assisted, Radiomics, Retrospective Studies, Tomography, X-Ray Computed, Tumor heterogeneity, Ubiquitin-Protein Ligases |
| Date Added | 2020/08/20 - 11:03:20 |
| Date Modified | 2020/08/20 - 11:03:20 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
