| Added by | liaudet-coopman |
|---|---|
| Group name | EquipeELC |
| Item Type | Journal Article |
| Title | TIF1? Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability |
| Creator | Pommier et al. |
| Author | Roxane M. Pommier |
| Author | Johann Gout |
| Author | David F. Vincent |
| Author | Lindsay B. Alcaraz |
| Author | Nicolas Chuvin |
| Author | Vanessa Arfi |
| Author | Sylvie Martel |
| Author | Bastien Kaniewski |
| Author | Guillaume Devailly |
| Author | Geneviève Fourel |
| Author | Pascal Bernard |
| Author | Caroline Moyret-Lalle |
| Author | Stéphane Ansieau |
| Author | Alain Puisieux |
| Author | Ulrich Valcourt |
| Author | Stéphanie Sentis |
| Author | Laurent Bartholin |
| Abstract | The transcription accessory factor TIF1?/TRIM33/RFG7/PTC7/Ectodermin functions as a tumor suppressor that promotes development and cellular differentiation. However, its precise function in cancer has been elusive. In the present study, we report that TIF1? inactivation causes cells to accumulate chromosomal defects, a hallmark of cancer, due to attenuations in the spindle assembly checkpoint and the post-mitotic checkpoint. TIF1? deficiency also caused a loss of contact growth inhibition and increased anchorage-independent growth in vitro and in vivo. Clinically, reduced TIF1? expression in human tumors correlated with an increased rate of genomic rearrangements. Overall, our work indicates that TIF1? exerts its tumor-suppressive functions in part by promoting chromosomal stability. |
| Publication | Cancer Research |
| Volume | 75 |
| Issue | 20 |
| Pages | 4335-4350 |
| Date | Oct 15, 2015 |
| Journal Abbr | Cancer Res. |
| Language | eng |
| DOI | 10.1158/0008-5472.CAN-14-3426 |
| ISSN | 1538-7445 |
| Library Catalog | PubMed |
| Extra | PMID: 26282171 |
| Tags | Animals, Carcinoma in Situ, Cell Cycle Checkpoints, Cell Line, Tumor, Cell Transformation, Neoplastic, Chromosomal Instability, Disease Models, Animal, Disease Progression, Down-Regulation, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Mice, Mice, Knockout, Neoplasms, original, Ploidies, Spindle Apparatus, Transcription Factors |
| Date Added | 2019/05/29 - 13:01:35 |
| Date Modified | 2019/05/29 - 13:01:48 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
