| Added by | ircm doc |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Circulating tumour cells and PD-L1-positive small extracellular vesicles: the liquid biopsy combination for prognostic information in patients with metastatic non-small cell lung cancer |
| Creator | Eslami-S et al. |
| Author | Zahra Eslami-S |
| Author | Luis Enrique Cortés-Hernández |
| Author | Léa Sinoquet |
| Author | Ludovic Gauthier |
| Author | Valentin Vautrot |
| Author | Laure Cayrefourcq |
| Author | Laure Avoscan |
| Author | William Jacot |
| Author | Marie Viala |
| Author | Quentin Dominique Thomas |
| Author | Pierre-Jean Lamy |
| Author | Xavier Quantin |
| Author | Jessica Gobbo |
| Author | Catherine Alix-Panabières |
| Abstract | BACKGROUND: Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and extracellular vesicles (EVs) are minimally invasive liquid biopsy biomarkers. This study investigated whether they predict prognosis, alone or in combination, in heterogenous unbiased non-small cell lung cancer (NSCLC) patients. METHODS: Plasma samples of 54 advanced NSCLC patients from a prospective clinical trial. CtDNA mutations were identified using the UltraSEEK? Lung Panel (MassARRAY® technology). PD-L1 expression was assessed in small EVs (sEVs) using an enzyme-linked immunosorbent assay. RESULTS: At least one ctDNA mutation was detected in 37% of patients. Mutations were not correlated with overall survival (OS) (HR?=?1.1, 95% CI?=?0.55; 1.83, P?=?0.980) and progression-free survival (PFS) (HR?=?1.00, 95% CI?=?0.57-1.76, P?=?0.991). High PD-L1+ sEV concentration was correlated with OS (HR?=?1.14, 95% CI?=?1.03-1.26, P?=?0.016), but not with PFS (HR?=?1.08, 95% CI?=?0.99-1.18, P?=?0.095). The interaction analysis suggested that PD-L1+ sEV correlation with PFS changed in function of CTC presence/absence (P interaction?=?0.036). The combination analysis highlighted worse prognosis for patients with CTCs and high PD-L1+ sEV concentration (HR?=?7.65, 95% CI?=?3.11-18.83, P? |
| Publication | British Journal of Cancer |
| Volume | 130 |
| Issue | 1 |
| Pages | 63-72 |
| Date | 2024-01 |
| Journal Abbr | Br J Cancer |
| Language | eng |
| DOI | 10.1038/s41416-023-02491-9 |
| ISSN | 1532-1827 |
| Short Title | Circulating tumour cells and PD-L1-positive small extracellular vesicles |
| Library Catalog | PubMed |
| Extra | PMID: 37973956 PMCID: PMC10781977 |
| Tags | B7-H1 Antigen, Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung, Extracellular Vesicles, Humans, Lung Neoplasms, Neoplastic Cells, Circulating, original, Prognosis, Prospective Studies |
| Date Added | 2025/01/13 - 11:59:56 |
| Date Modified | 2025/01/16 - 09:47:10 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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