| Added by | standudu |
|---|---|
| Group name | EquipeAT |
| Item Type | Journal Article |
| Title | Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study |
| Creator | van Hilst et al. |
| Author | Jony van Hilst |
| Author | Thijs de Rooij |
| Author | Sjors Klompmaker |
| Author | Majd Rawashdeh |
| Author | Francesca Aleotti |
| Author | Bilal Al-Sarireh |
| Author | Adnan Alseidi |
| Author | Zeeshan Ateeb |
| Author | Gianpaolo Balzano |
| Author | Frederik Berrevoet |
| Author | Bergthor Björnsson |
| Author | Ugo Boggi |
| Author | Olivier R. Busch |
| Author | Giovanni Butturini |
| Author | Riccardo Casadei |
| Author | Marco Del Chiaro |
| Author | Sophia Chikhladze |
| Author | Federica Cipriani |
| Author | Ronald van Dam |
| Author | Isacco Damoli |
| Author | Susan van Dieren |
| Author | Safi Dokmak |
| Author | Bjørn Edwin |
| Author | Casper van Eijck |
| Author | Jean-Marie Fabre |
| Author | Massimo Falconi |
| Author | Olivier Farges |
| Author | Laureano Fernández-Cruz |
| Author | Antonello Forgione |
| Author | Isabella Frigerio |
| Author | David Fuks |
| Author | Francesca Gavazzi |
| Author | Brice Gayet |
| Author | Alessandro Giardino |
| Author | Bas Groot Koerkamp |
| Author | Thilo Hackert |
| Author | Matthias Hassenpflug |
| Author | Irfan Kabir |
| Author | Tobias Keck |
| Author | Igor Khatkov |
| Author | Masa Kusar |
| Author | Carlo Lombardo |
| Author | Giovanni Marchegiani |
| Author | Ryne Marshall |
| Author | Krish V. Menon |
| Author | Marco Montorsi |
| Author | Marion Orville |
| Author | Matteo de Pastena |
| Author | Andrea Pietrabissa |
| Author | Ignaci Poves |
| Author | John Primrose |
| Author | Raffaele Pugliese |
| Author | Claudio Ricci |
| Author | Keith Roberts |
| Author | Bård Røsok |
| Author | Mushegh A. Sahakyan |
| Author | Santiago Sánchez-Cabús |
| Author | Per Sandström |
| Author | Lauren Scovel |
| Author | Leonardo Solaini |
| Author | Zahir Soonawalla |
| Author | F. Régis Souche |
| Author | Robert P. Sutcliffe |
| Author | Guido A. Tiberio |
| Author | Ale? Tomazic |
| Author | Roberto Troisi |
| Author | Ulrich Wellner |
| Author | Steven White |
| Author | Uwe A. Wittel |
| Author | Alessandro Zerbi |
| Author | Claudio Bassi |
| Author | Marc G. Besselink |
| Author | Mohammed Abu Hilal |
| Abstract | OBJECTIVE: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC. METHODS: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015. MIDP patients were matched to ODP patients in a 1:1 ratio. Main outcomes were radical (R0) resection, lymph node retrieval, and survival. RESULTS: In total, 1212 patients were included from 34 centers in 11 countries. Of 356 (29%) MIDP patients, 340 could be matched. After matching, the MIDP conversion rate was 19% (n = 62). Median blood loss [200?mL (60-400) vs 300?mL (150-500), P = 0.001] and hospital stay [8 (6-12) vs 9 (7-14) days, P < 0.001] were lower after MIDP. Clavien-Dindo grade ?3 complications (18% vs 21%, P = 0.431) and 90-day mortality (2% vs 3%, P > 0.99) were comparable for MIDP and ODP, respectively. R0 resection rate was higher (67% vs 58%, P = 0.019), whereas Gerota's fascia resection (31% vs 60%, P < 0.001) and lymph node retrieval [14 (8-22) vs 22 (14-31), P < 0.001] were lower after MIDP. Median overall survival was 28 [95% confidence interval (CI), 22-34] versus 31 (95% CI, 26-36) months (P = 0.929). CONCLUSIONS: Comparable survival was seen after MIDP and ODP for PDAC, but the opposing differences in R0 resection rate, resection of Gerota's fascia, and lymph node retrieval strengthen the need for a randomized trial to confirm the oncological safety of MIDP. |
| Publication | Annals of Surgery |
| Volume | 269 |
| Issue | 1 |
| Pages | 10-17 |
| Date | Jan 2019 |
| Journal Abbr | Ann. Surg. |
| Language | eng |
| DOI | 10.1097/SLA.0000000000002561 |
| ISSN | 1528-1140 |
| Short Title | Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA) |
| Library Catalog | PubMed |
| Extra | PMID: 29099399 |
| Tags | clinic |
| Date Added | 2019/05/29 - 15:32:42 |
| Date Modified | 2019/05/29 - 15:32:51 |
| Notes and Attachments | PubMed entry (Attachment) Version acceptée (Attachment) |
Institut de Recherche en Cancérologie de
