Research
Epitranscriptomics & Cancer Adaptation : A.David

Activities

Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

More..

Zotero public

Added by standudu
Group name EquipeCTCS
Item Type Journal Article
Title Serum NSE, MMP-9 and HER2 extracellular domain are associated with brain metastases in metastatic breast cancer patients: predictive biomarkers for brain metastases?
Creator Darlix et al.
Author Amélie Darlix
Author Pierre-Jean Lamy
Author Evelyne Lopez-Crapez
Author Antoine Laurent Braccini
Author Nelly Firmin
Author Gilles Romieu
Author William Jacot
Abstract Breast cancer (BC) is the second most common cause of brain metastases (BM). Predictive factors for BM have been widely studied in metastatic BC; however, there is no known serum tumor marker to accurately predict BM. Elevated serum S100ß protein and neuron-specific enolase (NSE) could reflect the brain damages induced by BM. Matrix metalloproteinase 9 (MMP-9) is involved in tumor invasion and metastatic dissemination, including BM. Also, HER2-amplified BC were shown to have a particular tropism for central nervous system (CNS). This study evaluated the correlation of these biomarkers with the presence of BM in metastatic BC patients. In this case-control study, 88 consecutive metastatic BC patients with BM (BM group) treated in our institution (2008-2015) were retrospectively selected, based on the availability of frozen serum samples for tumor marker determination. Patients were matched by age, tumor biology and number of previous metastatic chemotherapy lines to 162 metastatic BC patients without CNS involvement (control group). Serum NSE, MMP-9 and HER2 extracellular domain (ECD) levels were significantly higher in the BM group (p?=?0.0051, p?=?0.0062 and p?=?0.0057, respectively). In multivariate analysis, serum HER2 and MMP-9 levels accurately discriminated patients with BM: odds ratios 4.4 (p < 0.001; 95%CI: 1.9-9.6) for HER2 ECD and 3.5 (p?=?0.005; 95%CI: 1.5-8.4) for MMP-9. In multivariate analysis, HER2 ECD and NSE serum levels were independent prognostic factors in patients with BM. Serum HER2 ECD and MMP-9 appear to be associated with BM in metastatic BC patients. Their predictive value for BM still needs to be evaluated in further prospective studies.
Publication International Journal of Cancer
Volume 139
Issue 10
Pages 2299-2311
Date 11 15, 2016
Journal Abbr Int. J. Cancer
Language eng
DOI 10.1002/ijc.30290
ISSN 1097-0215
Short Title Serum NSE, MMP-9 and HER2 extracellular domain are associated with brain metastases in metastatic breast cancer patients
Library Catalog PubMed
Extra PMID: 27464303
Tags Aged, Biomarkers, Tumor, Brain Neoplasms, breast cancer, Breast Neoplasms, Case-Control Studies, cortresponding, Female, first-last-corresponding, Humans, last, Matrix Metalloproteinase 9, Middle Aged, original, Phosphopyruvate Hydratase, Receptor, ErbB-2, Retrospective Studies, S100 Calcium Binding Protein beta Subunit, tumor markers
Date Added 2019/05/31 - 12:58:19
Date Modified 2022/08/01 - 16:08:05
Notes and Attachments PubMed entry (Attachment)
Texte intégral (Attachment)


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés