| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Improving Patients' Life Quality after Radiotherapy Treatment by Predicting Late Toxicities |
| Creator | Lapierre et al. |
| Author | Ariane Lapierre |
| Author | Laura Bourillon |
| Author | Marion Larroque |
| Author | Tiphany Gouveia |
| Author | Céline Bourgier |
| Author | Mahmut Ozsahin |
| Author | André Pèlegrin |
| Author | David Azria |
| Author | Muriel Brengues |
| Abstract | Personalized treatment and precision medicine have become the new standard of care in oncology and radiotherapy. Because treatment outcomes have considerably improved over the last few years, permanent side-effects are becoming an increasingly significant issue for cancer survivors. Five to ten percent of patients will develop severe late toxicity after radiotherapy. Identifying these patients before treatment start would allow for treatment adaptation to minimize definitive side effects that could impair their long-term quality of life. Over the last decades, several tests and biomarkers have been developed to identify these patients. However, out of these, only the Radiation-Induced Lymphocyte Apoptosis (RILA) assay has been prospectively validated in multi-center cohorts. This test, based on a simple blood draught, has been shown to be correlated with late radiation-induced toxicity in breast, prostate, cervical and head and neck cancer. It could therefore greatly improve decision making in precision radiation oncology. This literature review summarizes the development and bases of this assay, as well as its clinical results and compares its results to the other available assays. |
| Publication | Cancers |
| Volume | 14 |
| Issue | 9 |
| Pages | 2097 |
| Date | 2022-04-22 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers14092097 |
| ISSN | 2072-6694 |
| Library Catalog | PubMed |
| Extra | Number: 9 PMID: 35565227 PMCID: PMC9099838 |
| Tags | first-last-coresponding, last, late toxicities prediction, personalized treatment, review |
| Date Added | 2023/11/23 - 12:48:16 |
| Date Modified | 2024/12/15 - 03:59:51 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
