| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | New Drugs for Targeted Radionuclide Therapy in Metastatic Prostate Cancer |
| Creator | Hébert et al. |
| Author | Kévin Hébert |
| Author | Paul Bodin-Cufi |
| Author | Cyril Fersing |
| Author | Emmanuel Deshayes |
| Abstract | Metastatic prostate cancer is a frequent and fatal disease. Targeted radionuclide therapy (TRT) has become a readily available therapeutic option since the approval of [177Lu]Lu-PSMA-617. Various molecules are currently being studied for TRT in prostate cancer. We review various combinations of isotopes and vectors being used to target prostate cancer cells and optimize pharmacokinetics. Promising innovations include chemical modifications to improve biodistribution, identification of new targets, and the use of novel radioisotopes such as ? emitters. PATIENT SUMMARY: Our mini review summarizes research on targeted radioactive drugs for treatment of metastatic prostate cancer. Several promising radioactive pharmaceuticals are being evaluated in clinical trials, but more studies are necessary before these can be used in routine clinical practice. |
| Publication | European Urology Focus |
| Volume | 10 |
| Issue | 4 |
| Pages | 514-517 |
| Date | 2024-07 |
| Journal Abbr | Eur Urol Focus |
| Language | eng |
| DOI | 10.1016/j.euf.2024.07.016 |
| ISSN | 2405-4569 |
| Library Catalog | PubMed |
| Extra | PMID: 39142998 |
| Tags | Dipeptides, first-last-coresponding, Heterocyclic Compounds, 1-Ring, Humans, Lutetium, Male, Metastatic prostate cancer, Molecular Targeted Therapy, Neoplasm Metastasis, Prostate-specific membrane antigen, Prostatic Neoplasms, Radioisotopes, Radiopharmaceuticals, review |
| Date Added | 2024/12/07 - 07:57:31 |
| Date Modified | 2024/12/15 - 10:32:27 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) |
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