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Epitranscriptomics & Cancer Adaptation : A.David

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Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

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Added by standudu
Group name EquipeCTCS
Item Type Journal Article
Title Isolated ipsilateral local recurrence of breast cancer: predictive factors and prognostic impact
Creator Houvenaeghel et al.
Author Gilles Houvenaeghel
Author Alexandre de Nonneville
Author Monique Cohen
Author Jean-Marc Classe
Author Fabien Reyal
Author Chafika Mazouni
Author Nicolas Chopin
Author Alejandra Martinez
Author Emile Daraï
Author Charles Coutant
Author Pierre-Emmanuel Colombo
Author Pierre Gimbergues
Author Marie-Pierre Chauvet
Author Anne-Sophie Azuar
Author Roman Rouzier
Author Christine Tunon de Lara
Author Xavier Muracciole
Author Aubert Agostini
Author Eric Lambaudie
Abstract BACKGROUND: Tumour features associated with isolated invasive breast cancer (BC) ipsilateral local recurrence (ILR) after breast conservative treatment (BCT) and consequences on overall survival (OS) are still debated. Our objective was to investigate these points. METHODS: Patients were retrospectively identified from a cohort of patients who underwent BCT for invasive BC in 16 cancer centres. End-points were ILR rate and OS. The impact of ILR on OS was assessed by multivariate analysis (MVA) for all patients and according to endocrine receptors (ERs) and grade or tumour subtypes. RESULTS: Of 15,570 patients, ILR rate was 3.1%. Cumulative ILR rates differed according to ERs/grade (ERs+/Grade2: HR 1.42, p?=?0.010; ERs+/Grade3: HR 1.41, p?=?0.067; ERs-: HR 2.14, p?
Publication Breast Cancer Research and Treatment
Volume 173
Issue 1
Pages 111-122
Date Jan 2019
Journal Abbr Breast Cancer Res. Treat.
Language eng
DOI 10.1007/s10549-018-4944-2
ISSN 1573-7217
Short Title Isolated ipsilateral local recurrence of breast cancer
Library Catalog PubMed
Extra PMID: 30238274
Tags clinic, Ipsilateral, Local recurrence, Prognosis, Survival
Date Added 2019/05/31 - 16:38:56
Date Modified 2019/05/31 - 16:39:07
Notes and Attachments PubMed entry (Attachment)


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