| Added by | celine.gongora |
|---|---|
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | Chemotherapy for Muscle-invasive Bladder Cancer: Impact of Cisplatin Delivery on Renal Function and Local Control Rate in the Randomized Phase III VESPER (GETUG-AFU V05) Trial |
| Creator | Culine et al. |
| Author | Valentin Harter |
| Author | Gwenaelle Gravis |
| Author | Aude Fléchon |
| Author | Christine Chevreau |
| Author | Hakim Mahammedi |
| Author | Brigitte Laguerre |
| Author | Aline Guillot |
| Author | Florence Joly |
| Author | Sophie Abadie-Lacourtoisie |
| Author | Lionnel Geoffrois |
| Author | Frédéric Di Fiore |
| Author | Guilhem Roubaud |
| Author | Philippe Barthélémy |
| Author | Eric Voog |
| Author | Sheik Emambux |
| Author | Camille Serrate |
| Author | Carolina Saldana |
| Author | Thierry Nguyen-Tan-Hon |
| Author | Yohann Loriot |
| Author | Jean-Christophe Eymard |
| Author | Olivier Huillard |
| Author | Nadine Houédé |
| Author | Jean-Philippe Spano |
| Author | Mounira El Demery |
| Author | Sabine Vieillot |
| Author | Tifenn L'Haridon |
| Author | Werner Hilgers |
| Author | Yves Allory |
| Author | Christian Pfister |
| Abstract | BACKGROUND: Cisplatin-based combination chemotherapy before surgery is the standard of care for muscle-invasive bladder cancer. However, the optimal chemotherapy modalities have not been precisely defined to date.
PATIENTS AND METHODS: In the VESPER trial, patients received after randomization either gemcitabine and cisplatin (GC, 4 cycles) or methotrexate, vinblastine, doxorubicin and cisplatin (dose dense [dd]-MVAC, 6 cycles). Creatinine clearance (CrCl) was calculated before each cycle according to the Cockroft and Gault formula. Definition criteria for local control after neoadjuvant chemotherapy included pathological complete response (ypT0N0), pathological downstaging ( |
| Publication | Clinical Genitourinary Cancer |
| Volume | 19 |
| Issue | 6 |
| Pages | 554-562 |
| Date | 2021-12 |
| Journal Abbr | Clin Genitourin Cancer |
| Language | eng |
| DOI | 10.1016/j.clgc.2021.08.005 |
| ISSN | 1938-0682 |
| Short Title | Chemotherapy for Muscle-invasive Bladder Cancer |
| Library Catalog | PubMed |
| Extra | PMID: 34602349 |
| Tags | Antineoplastic Combined Chemotherapy Protocols, Chemotherapy, Adjuvant, Cisplatin, Cisplatin-based chemotherapy, clinic, Cystectomy, Doxorubicin, Humans, Kidney, Methotrexate, Muscles, Neoadjuvant Therapy, Neoadjuvant treatment, Pathological downstaging, Perioperative chemotherapy, Retrospective Studies, Urinary Bladder Neoplasms, Vinblastine |
| Date Added | 2022/08/29 - 15:32:30 |
| Date Modified | 2022/08/29 - 16:33:30 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
