| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | [68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions |
| Creator | Rubira et al. |
| Author | Léa Rubira |
| Author | Charlotte Donzé |
| Author | Juliette Fouillet |
| Author | Benjamin Algudo |
| Author | Pierre Olivier Kotzki |
| Author | Emmanuel Deshayes |
| Author | Cyril Fersing |
| Abstract | The influence of several parameters involved in the 68Ga radiolabeling of FAPI-46 was studied at the scale of the automated reaction. Among the buffers tested, HEPES 0.3 M pH 4 allowed both high radiochemical purity (RCP) and radiochemical yield (RCY), without prepurification of 68Ga but after final purification of [68Ga]Ga-FAPI-46 on a C18 cartridge. A longer reaction time did not show significant benefit on the RCP, while higher loads of FAPI-46 and gentisic acid as anti-radiolysis compound allowed better RCY. |
| Publication | Applied Radiation and Isotopes: Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine |
| Volume | 206 |
| Pages | 111211 |
| Date | 2024-04 |
| Journal Abbr | Appl Radiat Isot |
| Language | eng |
| DOI | 10.1016/j.apradiso.2024.111211 |
| ISSN | 1872-9800 |
| Short Title | [68Ga]Ga-FAPI-46 synthesis on a GAIA® module system |
| Library Catalog | PubMed |
| Extra | PMID: 38309117 |
| Tags | Automated production, FAPI-46, Fibroblast, Gallium-68, Molecular imaging, original, Scientific |
| Date Added | 2024/12/07 - 07:57:46 |
| Date Modified | 2024/12/15 - 11:17:21 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
