| Added by | Patrick.Jouandin |
|---|---|
| Group name | EquipePJ |
| Item Type | Journal Article |
| Title | Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis |
| Creator | Jouandin et al. |
| Author | Patrick Jouandin |
| Author | Christian Ghiglione |
| Author | Stéphane Noselli |
| Abstract | When exposed to nutrient challenge, organisms have to adapt their physiology in order to balance reproduction with adult fitness. In mammals, ovarian follicles enter a massive growth phase during which they become highly dependent on gonadotrophic factors and nutrients. Somatic tissues play a crucial role in integrating these signals, controlling ovarian follicle atresia and eventually leading to the selection of a single follicle for ovulation. We used Drosophila follicles as a model to study the effect of starvation on follicle maturation. Upon starvation, Drosophila vitellogenic follicles adopt an 'atresia-like' behavior, in which some slow down their development whereas others enter degeneration. The mitotic-to-endocycle (M/E) transition is a critical step during Drosophila oogenesis, allowing the entry of egg chambers into vitellogenesis. Here, we describe a specific and transient phase during M/E switching that is paused upon starvation. The Insulin pathway induces the pausing of the M/E switch, blocking the entry of egg chambers into vitellogenesis. Pausing of the M/E switch involves a previously unknown crosstalk between FoxO, Cut and Notch that ensures full reversion of the process and rapid resumption of oogenesis upon refeeding. Our work reveals a novel genetic mechanism controlling the extent of the M/E switch upon starvation, thus integrating metabolic cues with development, growth and reproduction. |
| Publication | Development (Cambridge, England) |
| Volume | 141 |
| Issue | 15 |
| Pages | 3013-3021 |
| Date | 2014-08 |
| Journal Abbr | Development |
| Language | eng |
| DOI | 10.1242/dev.108399 |
| ISSN | 1477-9129 |
| Library Catalog | PubMed |
| Extra | PMID: 24993942 PMCID: PMC6514422 |
| Tags | Animals, Cell Cycle, Cytoplasm, dFoxO, Drosophila, Drosophila melanogaster, Drosophila Proteins, Female, first, Follicle, Food Deprivation, Forkhead Transcription Factors, Gene Expression Regulation, Green Fluorescent Proteins, M/E switch, Oocytes, Oogenesis, original, Ovarian Follicle, Ovulation, Ploidies, Receptors, Notch, Signal Transduction, Vitellogenesis |
| Date Added | 2023/02/17 - 16:44:20 |
| Date Modified | 2025/01/13 - 07:28:48 |
| Notes and Attachments | Full Text (Attachment) PubMed entry (Attachment) |
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