| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | IL-21 Signaling in the Tumor Microenvironment |
| Creator | Chabab et al. |
| Author | Ghita Chabab |
| Author | Nathalie Bonnefoy |
| Author | Virginie Lafont |
| Abstract | IL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can modulate innate and specific immunity activities. It is a potent stimulator of T and natural killer cell-mediated antitumor immunity but also has pro-inflammatory functions in many tissues and is involved in oncogenesis. It is important to understand IL-21 biology in these different situations to ensure the maximal benefit of therapeutic strategies targeting this cytokine. This chapter summarizes IL-21 characteristics and signaling, its role in immune system components, and its use in cancer immunotherapies. |
| Publication | Advances in Experimental Medicine and Biology |
| Volume | 1240 |
| Pages | 73-82 |
| Date | 2020 |
| Journal Abbr | Adv. Exp. Med. Biol. |
| Language | eng |
| DOI | 10.1007/978-3-030-38315-2_6 |
| ISSN | 0065-2598 |
| Library Catalog | PubMed |
| Extra | PMID: 32060889 |
| Tags | ?c Cytokine family, Animals, Antitumor activity, Carcinogenesis, Cytokine, ERK pathway, Humans, Immune cells, Interleukins, JAK-STAT pathways, Killer Cells, Natural, Lymphocytes, Neoplasms, PI3-kinase pathway, Pro-tumoral activity, Regulation, Signal Transduction, Signaling pathways, T-Lymphocytes, Tumor Microenvironment |
| Date Added | 2020/07/29 - 15:06:29 |
| Date Modified | 2020/07/29 - 15:06:29 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
