| Added by | adjiane.lab |
|---|---|
| Group name | EquipeAD |
| Item Type | Journal Article |
| Title | Paracrine Behaviors Arbitrate Parasite-Like Interactions Between Tumor Subclones |
| Creator | Noble et al. |
| Author | Robert J. Noble |
| Author | Viola Walther |
| Author | Christian Roumestand |
| Author | Michael E. Hochberg |
| Author | Urszula Hibner |
| Author | Patrice Lassus |
| Abstract | Explaining the emergence and maintenance of intratumor heterogeneity is an important question in cancer biology. Tumor cells can generate considerable subclonal diversity, which influences tumor growth rate, treatment resistance, and metastasis, yet we know remarkably little about how cells from different subclones interact. Here, we confronted two murine mammary cancer cell lines to determine both the nature and mechanisms of subclonal cellular interactions in vitro. Surprisingly, we found that, compared to monoculture, growth of the "winner" was enhanced by the presence of the "loser" cell line, whereas growth of the latter was reduced. Mathematical modeling and laboratory assays indicated that these interactions are mediated by the production of paracrine metabolites resulting in the winner subclone effectively "farming" the loser. Our findings add a new level of complexity to the mechanisms underlying subclonal growth dynamics. |
| Publication | Frontiers in Ecology and Evolution |
| Volume | 9 |
| Pages | 675638 |
| Date | 2021-07 |
| Journal Abbr | Front Ecol Evol |
| Language | eng |
| DOI | 10.3389/fevo.2021.675638 |
| ISSN | 2296-701X |
| Library Catalog | PubMed |
| Extra | PMID: 35096847 PMCID: PMC8794381 |
| Tags | beta-hydroxybutirate, cancer evolution, cnrs, corresponding, evolutionary game theory, intratumor clonal heterogeneity, lactate, last, Lotka - Volterra model, original, paracrine signaling, parasitism |
| Date Added | 2022/02/02 - 20:12:16 |
| Date Modified | 2024/09/30 - 18:19:36 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) |
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