| Added by | lklinares |
|---|---|
| Group name | EquipeLL |
| Item Type | Journal Article |
| Title | Zika Virus Growth in Human Kidney Cells Is Restricted by an Elevated Glucose Level |
| Creator | Reslan et al. |
| Author | Alawiya Reslan |
| Author | Juliano G. Haddad |
| Author | Liadrine Moukendza Koundi |
| Author | Philippe Desprès |
| Author | Jean-Loup Bascands |
| Author | Gilles Gadea |
| Abstract | Mosquito-borne Zika virus (ZIKV) became a real threat to human health due to the lack of vaccine and effective antiviral treatment. The virus has recently been responsible for a global outbreak leading to millions of infected cases. ZIKV complications were highlighted in adults with Guillain-Barré syndrome and in newborns with increasing numbers of congenital disorders ranging from mild developmental delays to fatal conditions. The ability of ZIKV to establish a long-term infection in diverse organs including the kidneys has been recently documented but the consequences of such a viral infection are still debated. Our study aimed to determine whether the efficiency of ZIKV growth in kidney cells relates to glucose concentration. Human kidney HK-2 cells were infected with different ZIKV strains in presence of normal and high glucose concentrations. Virological assays showed a decrease in viral replication without modifying entry steps (viral binding, internalization, fusion) under high glucose conditions. This decrease replication was associated with a lower virus progeny and increased cell viability when compared to ZIKV-infected HK-2 cells in normal glucose concentration. In conclusion, we showed for the first time that an elevated glucose level influences ZIKV replication level with an effect on kidney cell survival. |
| Publication | International Journal of Molecular Sciences |
| Volume | 22 |
| Issue | 5 |
| Pages | 2495 |
| Date | 2021-03-02 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms22052495 |
| ISSN | 1422-0067 |
| Library Catalog | PubMed |
| Extra | PMID: 33801335 PMCID: PMC7958337 |
| Tags | Cells, Cultured, diabetes, flavivirus, Glucose, high glucose, Humans, Kidney, kidney cells, last, original, Sweetening Agents, viral infection, viral replication, Virus Attachment, Virus Replication, Zika Virus, Zika Virus Infection |
| Date Added | 2024/12/03 - 09:12:56 |
| Date Modified | 2024/12/03 - 09:12:56 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
