| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer |
| Creator | Faget et al. |
| Author | Julien Faget |
| Author | Svenja Groeneveld |
| Author | Gael Boivin |
| Author | Martial Sankar |
| Author | Nadine Zangger |
| Author | Miguel Garcia |
| Author | Nicolas Guex |
| Author | Inti Zlobec |
| Author | Loïc Steiner |
| Author | Alessandra Piersigilli |
| Author | Ioannis Xenarios |
| Author | Etienne Meylan |
| Abstract | Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1+ neutrophils to disease progression. Depletion experiments showed that Gr1+ cells (1) favor tumor growth, (2) reduce T cell homing and prevent successful anti-PD1 immunotherapy, and (3) alter angiogenesis, leading to hypoxia and sustained Snail expression in lung cancer cells. In turn, Snail accelerated disease progression and increased intratumoral Cxcl2 secretion and neutrophil infiltration. Cxcl2 was produced mainly by neutrophils themselves in response to a factor secreted by Snail-expressing tumor cells. We therefore propose a vicious cycle encompassing neutrophils and Snail to maintain a deleterious tumor microenvironment. |
| Publication | Cell Reports |
| Volume | 21 |
| Issue | 11 |
| Pages | 3190-3204 |
| Date | Dec 12, 2017 |
| Journal Abbr | Cell Rep |
| Language | eng |
| DOI | 10.1016/j.celrep.2017.11.052 |
| ISSN | 2211-1247 |
| Library Catalog | PubMed |
| Extra | PMID: 29241546 |
| Tags | Adenocarcinoma, Adenocarcinoma of Lung, Animals, Antibodies, Monoclonal, Antigens, Ly, Chemokine CXCL2, CXCL2, Disease Models, Animal, Disease Progression, first-last-corresponding, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, hypoxia, immune exclusion, Leukocyte Reduction Procedures, lung cancer, Lung Neoplasms, MegaClust, Mice, Mice, Knockout, Neovascularization, Pathologic, neutrophil, Neutrophils, original, PD1, Prognosis, Programmed Cell Death 1 Receptor, Proto-Oncogene Proteins p21(ras), Signal Transduction, Snail, Snail Family Transcription Factors, Survival Analysis, Tumor Microenvironment, vascularization |
| Date Added | 2019/05/28 - 21:17:07 |
| Date Modified | 2019/12/16 - 17:46:49 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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