| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Long-term follow-up experience in anal canal cancer treated with Intensity-Modulated Radiation Therapy: Clinical outcomes, patterns of relapse and predictors of failure |
| Creator | de Meric de Bellefon et al. |
| Author | Maïlys de Meric de Bellefon |
| Author | Claire Lemanski |
| Author | Florence Castan |
| Author | Emmanuelle Samalin |
| Author | Thibault Mazard |
| Author | Alexis Lenglet |
| Author | Sylvain Demontoy |
| Author | Olivier Riou |
| Author | Carmen Llacer-Moscardo |
| Author | Pascal Fenoglietto |
| Author | Simon Thezenas |
| Author | Charles Debrigode |
| Author | Sabine Vieillot |
| Author | Sophie Gourgou |
| Author | David Azria |
| Abstract | BACKGROUND AND PURPOSE: To assess the long-term outcomes of patients with squamous cell carcinoma of the anal canal (SCCAC) treated with Intensity-Modulated Radiation Therapy (IMRT). MATERIAL AND METHODS: From 2007 to 2015, 193 patients were treated by IMRT for SCCAC. Radiotherapy delivered 45 Gy in 1.8 Gy daily-fractions to the primary tumor and elective nodal areas, immediately followed by a boost of 14.4-20 Gy to the primary tumor and involved nodes. Concurrent chemotherapy with 5-FU-mitomycin (MMC) or cisplatin was added for locally advanced tumors. Survivals were estimated by Kaplan-Meier method. Locoregional (LR) relapses were precisely assessed. Prognostic factors were evaluated by uni- and multivariate analyses. Late toxicity was scored according to the Common Toxicity Criteria for Adverse Events v4.0. RESULTS: Median follow-up was 70 months (range, 1-131). Forty-nine men (25%) and 144 women (75%) were analyzed. Median age was 62 years. Tumor stages were I, II, III and IV in 7%, 24%, 63% and 6% of cases, respectively. Chemotherapy was delivered in 167 patients (87%), mainly MMC (80%). Five-year OS, DFS, CFS and LR control rates were 74%, 68%, 66% and 85%, respectively. Forty-one patients (21%) had a relapse: 22 were LR, mostly in-field (68%). Predictors for LR failure were exclusive radiotherapy, chemotherapy lacking MMC and treatment breaks >3 days. Overall late toxicity ?grade 2 occurred in 43% of patients, with 24% grade 3 and one case of grade 4 (hematuria). CONCLUSION: CRT with IMRT assures excellent local control in locally advanced SCCAC with manageable long-term toxicity. Multicentric prospective trials are required to reinforce those results. |
| Publication | Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology |
| Volume | 144 |
| Pages | 141-147 |
| Date | 2020-03 |
| Journal Abbr | Radiother Oncol |
| Language | eng |
| DOI | 10.1016/j.radonc.2019.11.016 |
| ISSN | 1879-0887 |
| Short Title | Long-term follow-up experience in anal canal cancer treated with Intensity-Modulated Radiation Therapy |
| Library Catalog | PubMed |
| Extra | PMID: 31809980 |
| Tags | Anal Canal, Anal canal carcinoma, Antineoplastic Combined Chemotherapy Protocols, Anus Neoplasms, Carcinoma, Squamous Cell, Chemoradiotherapy, clinic, Female, first-last-coresponding, Fluorouracil, Follow-Up Studies, Humans, IMRT, last, Long-term follow-up, Male, Middle Aged, Neoplasm Recurrence, Local, Patterns of relapse, Prognostic factors, Prospective Studies, Radiotherapy, Intensity-Modulated, Survival |
| Date Added | 2023/11/23 - 12:48:28 |
| Date Modified | 2024/12/15 - 04:09:56 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
