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Epitranscriptomics & Cancer Adaptation : A.David

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Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

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Group name EquipeCTCS
Item Type Journal Article
Title Impact of molecular testing on the surgical management of advanced epithelial ovarian cancer
Creator Colombo et al.
Author Pierre-Emmanuel Colombo
Author Christophe Taoum
Author Michel Fabbro
Author Stanislas Quesada
Author Philippe Rouanet
Author Isabelle Ray-Coquard
Abstract Ovarian carcinoma remains the most lethal gynaecologic malignancy. Half of all high-grade serous ovarian cancers (HGSOCs) have a homologous recombination deficiency (HRD) with regard to the repair of double-strand DNA breaks and are candidate to receive maintenance treatment with PARP inhibitors. While a wealth of literature exists regarding the therapeutic guidance of patients from a medical standpoint, the influence of the HRD status on the surgical outlook has been comparatively limited. In this review, the clinical and biological features of advanced ovarian cancers with BRCA1/2 mutation and/or HRD status are considered with particular reference to their impact on the surgical management and on the medico-surgical sequence. The modification of the surgical indications according to the results of molecular testing in first-line and recurrent settings are discussed.
Publication Critical Reviews in Oncology/Hematology
Volume 202
Pages 104469
Date 2024-10
Journal Abbr Crit Rev Oncol Hematol
Language eng
DOI 10.1016/j.critrevonc.2024.104469
ISSN 1879-0461
Library Catalog PubMed
Extra PMID: 39111459
Tags BRCA mutation, BRCA1 Protein, BRCA2 Protein, Carcinoma, Ovarian Epithelial, Disease Management, Female, first, first-last-corresponding, First-line treatement, Homologous Recombination Deficiency (HRD), Humans, Lymphadenectomy, Mutation, Ovarian cancer, Ovarian Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Residual disease, review, Surgery
Date Added 2025/01/16 - 11:46:52
Date Modified 2025/01/16 - 11:47:59
Notes and Attachments PubMed entry (Attachment)


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