| Added by | andrei.turtoi |
|---|---|
| Last modified by | standudu |
| Group name | EquipeAT |
| Item Type | Journal Article |
| Title | Microvascular invasion is a major prognostic factor after pancreatico-duodenectomy for adenocarcinoma |
| Creator | Panaro et al. |
| Author | Fabrizio Panaro |
| Author | Tarek Kellil |
| Author | Julie Vendrell |
| Author | Valentina Sega |
| Author | Regis Souche |
| Author | Tullio Piardi |
| Author | Piera Leon |
| Author | Christophe Cassinotto |
| Author | Eric Assenat |
| Author | Edoardo Rosso |
| Author | Francis Navarro |
| Abstract | BACKGROUND: Microvascular invasion (MVI) has been proved to be poor prognostic factor in many cancers. To date, only one study published highlights the relationship between this factor and the natural history of pancreatic cancer. The aim of this study was to assess the impact of MVI, on disease-free survival (DFS) and overall survival (OS), after pancreatico-duodenectomy (PD) for pancreatic head adenocarcinoma. Secondarily, we aim to demonstrate that MVI is the most important factor to predict OS after surgery compared with resection margin (RM) and lymph node (LN) status. MATERIALS AND METHODS: Between January 2015 and December 2017, 158 PD were performed in two hepato-bilio-pancreatic (HBP) centers. Among these, only 79 patients fulfilled the inclusion criteria of the study. Clinical-pathological data and outcomes were retrospectively analyzed from a prospectively maintained database. RESULTS: Of the 79 patients in the cohort, MVI was identified in 35 (44.3%). In univariate analysis, MVI (P?=?.012 and P??0.226 had a negative impact on OS (P?=?.044). In multivariate analysis, MVI and RM persisted as independent prognostic factors of DFS (P?=?.0075 and P?=?.0098, respectively) and OS (P? |
| Publication | Journal of Surgical Oncology |
| Volume | 120 |
| Issue | 3 |
| Pages | 483-493 |
| Date | 2019-09 |
| Journal Abbr | J Surg Oncol |
| Language | eng |
| DOI | 10.1002/jso.25580 |
| ISSN | 1096-9098 |
| Library Catalog | PubMed |
| Extra | PMID: 31197842 |
| Tags | Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Chemotherapy, Adjuvant, Deoxycytidine, Disease-Free Survival, ductal pancreatic adenocarcinoma, Female, Fluorouracil, Humans, Leucovorin, long-term outcomes, Male, microvascular invasion, Microvessels, Neovascularization, Pathologic, original, Pancreatic Neoplasms, pancreatico-duodenectomy, Pancreaticoduodenectomy, Prognosis, prognostic factor, Retrospective Studies |
| Date Added | 2022/08/30 - 10:50:36 |
| Date Modified | 2022/08/30 - 16:39:52 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
