| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients |
| Creator | Kapoor et al. |
| Author | Suman Kapoor |
| Author | Lucia Mihalovi?ová |
| Author | Ekaterina Pisareva |
| Author | Brice Pastor |
| Author | Alexia Mirandola |
| Author | Joe Bryant |
| Author | Anna Philip Princy |
| Author | Salem Chouaib |
| Author | Alain Roger Thierry |
| Abstract | We examined from a large exploratory study cohort of COVID-19 patients (N = 549) a validated panel of neutrophil extracellular traps (NETs) markers in different categories of disease severity. Neutrophil elastase (NE), myeloperoxidase (MPO), and circulating nuclear DNA (cir-nDNA) levels in plasma were seen to gradually and significantly (p < 0.0001) increase with the disease severity: mild (3.7, 48.9, and 15.8 ng/mL, respectively); moderate (9.8, 77.5, and 27.7 ng/mL, respectively); severe (11.7, 99.5, and 29.0 ng/mL, respectively); and critical (13.1, 110.2, and 46.0 ng/mL, respectively); and are also statistically different with healthy individuals (N = 140; p < 0.0001). All observations made in relation to the Delta variant-infected patients are in line with Omicron-infected patients. We unexpectedly observed significantly higher levels of NETs in asymptomatic individuals as compared to healthy subjects (p < 0.0001). Moreover, the balance of cir-nDNA and circulating mitochondrial DNA level was affected in COVID-19 infected patients attesting to mitochondrial dysfunction. |
| Publication | iScience |
| Volume | 27 |
| Issue | 5 |
| Pages | 109573 |
| Date | 2024-05-17 |
| Journal Abbr | iScience |
| Language | eng |
| DOI | 10.1016/j.isci.2024.109573 |
| ISSN | 2589-0042 |
| Library Catalog | PubMed |
| Extra | PMID: 38660409 PMCID: PMC11039348 |
| Tags | Health sciences, Medical microbiology, Public health |
| Date Added | 2024/10/07 - 16:07:08 |
| Date Modified | 2024/10/07 - 16:07:08 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
