| Added by | eric_julien |
|---|---|
| Group name | EquipeEJ |
| Item Type | Journal Article |
| Title | From genetics to epigenetics: the tale of Polycomb group and trithorax group genes |
| Creator | Grimaud et al. |
| Author | Charlotte Grimaud |
| Author | Nicolas Nègre |
| Author | Giacomo Cavalli |
| Abstract | The Polycomb gene was discovered 60 years ago as a mutation inducing a particular homeotic phenotype. Subsequent work showed that Polycomb is a general repressor of homeotic genes. Other genes with similar function were identified and named Polycomb group (PcG) genes, while trithorax group (trxG) genes were shown to counteract PcG-mediated repression of homeotic genes. We now know that PcG and trxG proteins are conserved factors that regulate hundreds of different genomic loci. A sophisticated pathway is responsible for recruitment of these proteins at regulatory regions that were named PcG and trxG response elements (PRE and TRE). Once recruited to their targets, multimeric PcG and trxG protein complexes regulate transcription by modulating chromatin structure, in particular via deposition of specific post-translational histone modification marks and control of chromatin accessibility, as well as regulation of the three-dimensional nuclear organization of PRE and TRE. Here, we recapitulate the history of PcG and trxG gene discovery, we review the current evidence on their molecular function and, based on this evidence, we propose a revised classification of genes involved in PcG and trxG regulatory pathways. |
| Publication | Chromosome Research: An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology |
| Volume | 14 |
| Issue | 4 |
| Pages | 363-375 |
| Date | 2006 |
| Journal Abbr | Chromosome Res. |
| Language | eng |
| DOI | 10.1007/s10577-006-1069-y |
| ISSN | 0967-3849 |
| Short Title | From genetics to epigenetics |
| Library Catalog | PubMed |
| Extra | PMID: 16821133 |
| Tags | Animals, Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Drosophila melanogaster, Drosophila Proteins, Epigenesis, Genetic, Gene Silencing, Genes, Homeobox, Histones, Methylation, Mutation, Polycomb Repressive Complex 1, Response Elements |
| Date Added | 2018/09/26 - 15:50:01 |
| Date Modified | 2018/09/26 - 15:50:01 |
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