| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Liver venous deprivation versus associating liver partition and portal vein ligation for staged hepatectomy for colo-rectal liver metastases: a comparison of early and late kinetic growth rates, and perioperative and oncological outcomes |
| Creator | Cassese et al. |
| Author | Gianluca Cassese |
| Author | Roberto Ivan Troisi |
| Author | Salah Khayat |
| Author | Federico Tomassini |
| Author | Fabrizio Panaro |
| Author | Boris Guiu |
| Abstract | BACKGROUND: Different techniques have been developed to optimize the Future Liver Remnant (FLR). Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) and liver venous deprivation (LVD) have shown the higher hypertrophy rates, but their place in clinical practice is still debated. METHODS: Thirty-two consecutive ALPPS and LVD procedures for CRLM performed between December 2015 and December 2019 were included. This retrospective study evaluated kinetic growth rates (KGR) as primary outcome, and perioperative and oncological outcomes as secondary endpoints. RESULTS: A total of 17 patients underwent LVD before surgery, whereas 15 underwent ALPPS. On early evaluation (7 vs 9 days, respectively), KGR did not differ between ALPPS and LVD cohort (0.8% per day vs 0.3% per day, p = 0.70; 23 cc/day vs 26 cc/day, p = 0.31). Late evaluation (21 vs 9 days) showed a KGR significantly decreased in the LVD group (0.6% per day vs 0.2% per day, p = 0.21; 20 cc/day vs 10 cc/day p = 0.02). Mean FLR-V increase was comparable in the two groups (60% vs 49%, p 0.32). Successful resection rate was 100% and 94% in LVD and ALPPS group, respectively. The hospital stay (p < 0.0001) and severe complications rate (p = 0.05) were lower after LVD. One and 3-years overall survival (OS) were 72,7% and 27,4% in the ALPSS group, versus 81,3% and 54,7% in LVD group (p = 0.10). The Median DFS was comparable between both techniques (6.1 months and 5.9 respectively, p = 0.66). CONCLUSIONS: LVD and ALPPS shows similar KGR during the early period following preparation as well as similar survival outcomes. Hospital stay and severe complications are lower after LVD. |
| Publication | Surgical Oncology |
| Volume | 43 |
| Pages | 101812 |
| Date | 2022-08 |
| Journal Abbr | Surg Oncol |
| Language | eng |
| DOI | 10.1016/j.suronc.2022.101812 |
| ISSN | 1879-3320 |
| Short Title | Liver venous deprivation versus associating liver partition and portal vein ligation for staged hepatectomy for colo-rectal liver metastases |
| Library Catalog | PubMed |
| Extra | PMID: 35820263 |
| Tags | ALPPS, Associated liver partition and portal vein ligation for staged hepatectomy, clinic, Hepatectomy, Humans, Ligation, Liver Neoplasms, liver surgery outcomes, Liver Venous Deprivation, Portal Vein, Retrospective Studies, Treatment Outcome |
| Date Added | 2023/02/25 - 11:49:36 |
| Date Modified | 2024/03/01 - 09:41:52 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
