| Added by | mollevi |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Kinetics of circulating cell-free DNA for biomedical applications: critical appraisal of the literature |
| Creator | Khier and Lohan |
| Author | Sonia Khier |
| Author | Laura Lohan |
| Abstract | Circulating cell-free DNA is considered as one of the major breakthroughs in the field of innovative diagnosis, used as a liquid biopsy. The kinetic parameters of a biomarker are mandatory to assess its usefulness as a diagnostic tool. Obtaining precise mathematical values for the kinetic parameters (e.g., half-life) is then crucial because it could be used for therapeutic monitoring as a prognostic factor. However, little is known about the intrinsic properties of circulating cell-free DNA, more especially, its kinetic properties within the organism. We summarized the basic principles that may affect the kinetics of circulating cell-free DNA within the organism in the light of biological and clinical evidence. We also meta-analyzed the reported data in the literature and the methodologies that have been used to study the kinetic parameters of human circulating cell-free DNA in vivo. |
| Publication | Future science OA |
| Volume | 4 |
| Issue | 4 |
| Pages | FSO295 |
| Date | Apr 2018 |
| Journal Abbr | Future Sci OA |
| Language | eng |
| DOI | 10.4155/fsoa-2017-0140 |
| ISSN | 2056-5623 |
| Short Title | Kinetics of circulating cell-free DNA for biomedical applications |
| Library Catalog | PubMed |
| Extra | PMID: 29682327 PMCID: PMC5905581 |
| Tags | cell-free DNA, half-life, original, pharmacokinetics |
| Date Added | 2018/11/13 - 17:24:58 |
| Date Modified | 2019/05/21 - 13:10:47 |
Institut de Recherche en Cancérologie de
