| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients' Profiles With Oxaliplatin-Induced Peripheral Neuropathy |
| Creator | Kerckhove et al. |
| Author | Nicolas Kerckhove |
| Author | Marie Selvy |
| Author | Céline Lambert |
| Author | Coralie Gonneau |
| Author | Gabrielle Feydel |
| Author | Caroline Pétorin |
| Author | Agnès Vimal-Baguet |
| Author | Sergey Melnikov |
| Author | Sharif Kullab |
| Author | Mohamed Hebbar |
| Author | Olivier Bouché |
| Author | Florian Slimano |
| Author | Vincent Bourgeois |
| Author | Valérie Lebrun-Ly |
| Author | Frédéric Thuillier |
| Author | Thibault Mazard |
| Author | David Tavan |
| Author | Kheir Eddine Benmammar |
| Author | Brigitte Monange |
| Author | Mohamed Ramdani |
| Author | Denis Péré-Vergé |
| Author | Floriane Huet-Penz |
| Author | Ahmed Bedjaoui |
| Author | Florent Genty |
| Author | Cécile Leyronnas |
| Author | Jérôme Busserolles |
| Author | Vincent Pinon |
| Author | Denis Pezet |
| Author | David Balayssac |
| Abstract | Oxaliplatin, a pivotal drug in the management of colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN) in a third of cancer survivors. Based on a previous cross-sectional study assessing oxaliplatin-related sensory CIPN in colorectal cancer survivors, a secondary analysis was designed to explore the possibility that different clusters of patients may co-exist among a cohort of patients with oxaliplatin-related CIPN. Other objectives were to characterize these clusters considering CIPN severity, anxiety, depression, health-related quality of life (HRQOL), patients' characteristics and oxaliplatin treatments. Among the 96 patients analyzed, three clusters were identified (cluster 1: 52, cluster 2: 34, and cluster 3: 10 patients). Clusters were significantly different according to CIPN severity and the proportion of neuropathic pain (cluster 1: low, cluster 2: intermediate, and cluster 3: high). Anxiety, depressive disorders and HRQOL alteration were lower in cluster 1 in comparison to clusters 2 and 3, but not different between clusters 2 and 3. This study underlines that patients with CIPN are not a homogenous group, and that CIPN severity is associated with psychological distress and a decline of HRQOL. Further studies are needed to explore the relation between clusters and CIPN management. |
| Publication | Frontiers in Pharmacology |
| Volume | 12 |
| Pages | 744085 |
| Date | 2021 |
| Journal Abbr | Front Pharmacol |
| Language | eng |
| DOI | 10.3389/fphar.2021.744085 |
| ISSN | 1663-9812 |
| Short Title | Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group |
| Library Catalog | PubMed |
| Extra | PMID: 34803689 PMCID: PMC8599933 |
| Tags | chemotherapy-induced peripheral neuropathy, colorectal cancer, neuropathic pain, oxaliplatin |
| Date Added | 2022/08/30 - 16:18:50 |
| Date Modified | 2024/10/10 - 16:52:34 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) Texte intégral (Attachment) |
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