| Added by | jacques.colinge |
|---|---|
| Group name | EquipeJC |
| Item Type | Journal Article |
| Title | Modeling the Simultaneous Dynamics of Proteins in Blood Plasma and the Cerebrospinal Fluid in Human In Vivo |
| Creator | Giroux et al. |
| Author | Pierre Giroux |
| Author | Jérôme Vialaret |
| Author | Jana Kindermans |
| Author | Audrey Gabelle |
| Author | Luc Bauchet |
| Author | Christophe Hirtz |
| Author | Sylvain Lehmann |
| Author | Jacques Colinge |
| Abstract | The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling, such as in Alzheimer's disease, and to provide informative data regarding drug efficacy or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net result of not only protein synthesis and degradation but also transport across biological compartments. We report an accurate 3-biological compartment model able to simultaneously account for the protein dynamics observed in blood plasma and the cerebrospinal fluid (CSF) including a hidden central nervous system (CNS) compartment. We successfully applied this model to 69 proteins of a single individual displaying similar or very different dynamics in plasma and CSF. This study puts a strong emphasis on the methods and tools needed to develop this type of model. We believe that it will be useful to any researcher dealing with protein dynamics data modeling. |
| Publication | Journal of Proteome Research |
| Volume | 23 |
| Issue | 7 |
| Pages | 2408-2418 |
| Date | 2024-07-05 |
| Journal Abbr | J Proteome Res |
| Language | eng |
| DOI | 10.1021/acs.jproteome.4c00059 |
| ISSN | 1535-3907 |
| Library Catalog | PubMed |
| Extra | PMID: 38857467 PMCID: PMC11232576 |
| Tags | Alzheimer Disease, Blood Proteins, cerebrospinal fluid, Cerebrospinal Fluid Proteins, corresponding, first, Humans, last, Models, Biological, original, pharmacokinetics, phd, physiology, protein dynamics, proteomics |
| Date Added | 2024/09/08 - 16:55:42 |
| Date Modified | 2024/09/08 - 17:01:14 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
