| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Association of CD206 Protein Expression with Immune Infiltration and Prognosis in Patients with Triple-Negative Breast Cancer |
| Creator | Bobrie et al. |
| Author | Océane Massol |
| Author | Jeanne Ramos |
| Author | Caroline Mollevi |
| Author | Evelyne Lopez-Crapez |
| Author | Nathalie Bonnefoy |
| Author | Florence Boissière-Michot |
| Author | William Jacot |
| Abstract | Background: Triple-negative breast cancers (TNBCs) have a worse prognosis, but might respond to immunotherapies. Macrophages are plastic cells that can adopt various phenotypes and functions. Although they are a major immune population in TNBCs, the relationship between tumor-associated macrophages (TAMs) and TNBC progression has been rarely explored, with controversial results. Methods: We evaluated the prognostic impact of TAMs, quantified by immunohistochemistry with anti-CD68, -IRF8, -CD163, and -CD206 antibodies, in a well-described cohort of 285 patients with non-metastatic TNBC. Results: CD68 (p = 0.008), IRF8 (p = 0.001), and CD163 (p < 0.001) expression positively correlated with higher tumor grade, while CD206 was associated with smaller tumor size (p < 0.001). All macrophage markers were associated with higher tumor-infiltrating lymphocyte numbers and PD-L1 expression. Univariate survival analyses reported a significant positive correlation between CD163+ or CD206+ TAMs and relapse-free survival (respectively: HR = 0.52 [0.28?0.97], p = 0.027, and HR = 0.51 [0.31?0.82], p = 0.005), and between CD206+ TAMs and overall survival (HR = 0.54 [0.35?0.83], p = 0.005). In multivariate analysis, there was a trend for an association between CD206+ TAMs and relapse-free survival (HR = 0.63 [0.33?1.04], p = 0.073). Conclusions: These data suggest that CD206 expression defines a TAM subpopulation potentially associated with favorable outcomes in patients with TNBC. CD206 expression might identify an immune TNBC subgroup with specific therapeutic options. |
| Publication | Cancers |
| Volume | 14 |
| Issue | 19 |
| Pages | 4829 |
| Date | 2022-10-03 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers14194829 |
| ISSN | 2072-6694 |
| Library Catalog | PubMed |
| Extra | PMID: 36230752 PMCID: PMC9564167 |
| Tags | CD163, CD206, CD68, IRF8, triple-negative breast cancer (TNBC), tumor-associated macrophages (TAM) |
| Date Added | 2023/11/15 - 10:25:45 |
| Date Modified | 2023/11/15 - 10:25:45 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
