| Added by | Cavailles |
|---|---|
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses |
| Creator | Balaguer et al. |
| Author | Patrick Balaguer |
| Author | Vanessa Delfosse |
| Author | Marina Grimaldi |
| Author | William Bourguet |
| Abstract | Endocrine-disrupting chemicals (EDCs) represent a broad class of exogenous substances that cause adverse effects in the endocrine system mainly by interacting with nuclear hormone receptors (NRs). Humans are generally exposed to low doses of pollutants, and current researches aim at deciphering the mechanisms accounting for the health impact of EDCs at environmental concentrations. Our correlative analysis of structural, interaction and cell-based data has revealed a variety of, sometimes unexpected, binding modes, reflecting a wide range of EDC affinities and specificities. Here, we present a few representative examples to illustrate various means by which EDCs achieve high-affinity binding to NRs. These examples include the binding of the mycoestrogen ?-zearalanol to estrogen receptors, the covalent interaction of organotins with the retinoid X- and peroxisome proliferator-activated receptors, and the cooperative binding of two chemicals to the pregnane X receptor. We also discuss some hypotheses that could further explain low-concentration effects of EDCs with weaker affinity towards NRs. |
| Publication | Comptes Rendus Biologies |
| Volume | 340 |
| Issue | 9-10 |
| Pages | 414-420 |
| Date | 2017 Sep - Oct |
| Journal Abbr | C. R. Biol. |
| Language | eng |
| DOI | 10.1016/j.crvi.2017.08.002 |
| ISSN | 1768-3238 |
| Library Catalog | PubMed |
| Extra | PMID: 29126514 |
| Tags | Animals, Endocrine Disruptors, Humans, Low doses, Nuclear receptors, Receptors, Cytoplasmic and Nuclear, review |
| Date Added | 2019/05/16 - 11:26:09 |
| Date Modified | 2019/05/16 - 11:39:24 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
