| Added by | mollevi |
|---|---|
| Last modified by | jacques.colinge |
| Group name | EquipeJC |
| Item Type | Journal Article |
| Title | Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage |
| Creator | Bhattacharya et al. |
| Author | A. Bhattacharya |
| Author | A. N. Hegazy |
| Author | N. Deigendesch |
| Author | L. Kosack |
| Author | J. Cupovic |
| Author | R. K. Kandasamy |
| Author | A. Hildebrandt |
| Author | D. Merkler |
| Author | A. A. Kuhl |
| Author | B. Vilagos |
| Author | C. Schliehe |
| Author | I. Panse |
| Author | K. Khamina |
| Author | H. Baazim |
| Author | I. Arnold |
| Author | L. Flatz |
| Author | H. C. Xu |
| Author | P. A. Lang |
| Author | A. Aderem |
| Author | A. Takaoka |
| Author | G. Superti-Furga |
| Author | J. Colinge |
| Author | B. Ludewig |
| Author | M. Lohning |
| Author | A. Bergthaler |
| Abstract | Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide. Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional changes in the redox pathways in the liver, including downregulation of superoxide dismutase 1 (Sod1). Sod1(-/-) mice exhibited increased inflammation and aggravated liver damage upon viral infection, which was independent of T and NK cells and could be ameliorated by antioxidant treatment. Type I interferon (IFN-I) led to a downregulation of Sod1 and caused oxidative liver damage in Sod1(-/-) and wild-type mice. Genetic and pharmacological ablation of the IFN-I signaling pathway protected against virus-induced liver damage. These results delineate IFN-I mediated oxidative stress as a key mediator of virus-induced liver damage and describe a mechanism of innate-immunity-driven pathology, linking IFN-I signaling with antioxidant host defense and infection-associated tissue damage. VIDEO ABSTRACT. |
| Publication | Immunity |
| Volume | 43 |
| Pages | 974-86 |
| Date | Nov 17 2015 |
| Journal Abbr | Immunity |
| DOI | 10.1016/j.immuni.2015.10.013 |
| ISSN | 1097-4180 (Electronic) 1074-7613 (Linking) |
| Tags | original |
| Date Added | 2018/11/14 - 11:48:35 |
| Date Modified | 2019/05/14 - 20:59:57 |
| Notes and Attachments | (Note) (Note) 26588782 (Attachment) |
Institut de Recherche en Cancérologie de
