| Added by | pcoopman |
|---|---|
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer |
| Creator | Mcheik et al. |
| Author | Soha Mcheik |
| Author | Leticia Aptecar |
| Author | Peter Coopman |
| Author | Véronique D'Hondt |
| Author | Gilles Freiss |
| Abstract | In this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradictory functions, we discuss PTPN13 implication in the FAS and oncogenic tyrosine kinase signaling pathways and in the associated biological activities, as well as its post-transcriptional and epigenetic regulation. Then, we describe PTPN13 clinical significance as a prognostic marker in different cancer types and its impact on anti-cancer treatment sensitivity. Finally, we present future research axes following recent findings on its role in cell junction regulation that implicate PTPN13 in cell death and cell migration, two major hallmarks of tumor formation and progression. |
| Publication | Biomolecules |
| Volume | 10 |
| Issue | 12 |
| Date | 2020-12-11 |
| Journal Abbr | Biomolecules |
| Language | eng |
| DOI | 10.3390/biom10121659 |
| ISSN | 2218-273X |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 33322542 PMCID: PMC7763032 |
| Tags | cancer, cell signaling, first-last-corresponding, oncogene, PTPN13, review, top, tumor suppressor |
| Date Added | 2021/03/15 - 17:07:11 |
| Date Modified | 2021/03/19 - 14:52:38 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
