| Added by | pcoopman |
|---|---|
| Last modified by | standudu |
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | [New approaches for protein-protein interaction study] |
| Creator | Béganton et al. |
| Author | Benoît Béganton |
| Author | Etienne Coyaud |
| Author | Alain Mangé |
| Author | Jérôme Solassol |
| Abstract | The proteome is a dynamic system in which protein-protein interactions play a crucial role to model together the cellular phenotype. However, given the inherent limitation of the available technologies to depict the dynamic nature of these interactions, identify protein-protein interaction has for a long time represented an important challenge in proteomic. The recent development of BioID and APEX, two proximity-dependent labeling technologies, opens today new perspectives and yet start changing our vision of protein-protein interaction, and more globally our vision of the proteome. In this review, we describe the recent and conventional tools available to study protein-protein interactions, compare the advantages and limitations of these technics, and discuss the recent progress brought by the proximity-dependent labelling to complete our vision of the proteome, and thus better understand cellular mechanisms. |
| Publication | Medecine Sciences: M/S |
| Volume | 35 |
| Issue | 3 |
| Pages | 223-231 |
| Date | Mar 2019 |
| Journal Abbr | Med Sci (Paris) |
| Language | fre |
| DOI | 10.1051/medsci/2019035 |
| ISSN | 1958-5381 |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 30931906 |
| Tags | Animals, Biotinylation, first-last-corresponding, Humans, Protein Binding, Protein Interaction Domains and Motifs, Protein Interaction Maps, Proteome, review, Staining and Labeling |
| Date Added | 2019/09/13 - 10:04:18 |
| Date Modified | 2020/10/04 - 14:01:59 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
