| Added by | pcoopman |
|---|---|
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity |
| Creator | Lacombe et al. |
| Author | Jérôme Lacombe |
| Author | Muriel Brengues |
| Author | Alain Mangé |
| Author | Céline Bourgier |
| Author | Sophie Gourgou |
| Author | André Pèlegrin |
| Author | Mahmut Ozsahin |
| Author | Jérôme Solassol |
| Author | David Azria |
| Abstract | BACKGROUND: Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conversely, proteomics approaches are not much developed, despite their advantages. METHODS: We used the isobaric tags for relative and absolute quantitation (iTRAQ) proteomic approach to analyze differences in protein expression levels in ex-vivo irradiated (8?Gy) T lymphocytes from patients with grade???2 radiation-induced breast fibrosis (grade???2 bf+) and patients with grade? |
| Publication | Radiation Oncology (London, England) |
| Volume | 14 |
| Issue | 1 |
| Pages | 142 |
| Date | Aug 09, 2019 |
| Journal Abbr | Radiat Oncol |
| Language | eng |
| DOI | 10.1186/s13014-019-1351-8 |
| ISSN | 1748-717X |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 31399108 PMCID: PMC6688300 |
| Tags | AK2, first-last-corresponding, Normal tissue radiotoxicity, original, Radiation-induced breast fibrosis, Radiosensitivity, Radiotherapy |
| Date Added | 2019/09/13 - 10:04:01 |
| Date Modified | 2023/11/15 - 16:33:32 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
