| Added by | pcoopman |
|---|---|
| Last modified by | standudu |
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | Circulating Cell Free Tumor DNA Detection as a Routine Tool forLung Cancer Patient Management |
| Creator | Vendrell et al. |
| Author | Julie A. Vendrell |
| Author | Frédéric Tran Mau-Them |
| Author | Benoît Béganton |
| Author | Sylvain Godreuil |
| Author | Peter Coopman |
| Author | Jérôme Solassol |
| Abstract | Circulating tumoral DNA (ctDNA), commonly named "liquid biopsy", has emerged as a new promising noninvasive tool to detect biomarker in several cancers including lung cancer. Applications involving molecular analysis of ctDNA in lung cancer have increased and encompass diagnosis, response to treatment, acquired resistance and prognosis prediction, while bypassing the problem of tumor heterogeneity. ctDNA may then help perform dynamic genetic surveillance in the era of precision medicine through indirect tumoral genomic information determination. The aims of this review were to examine the recent technical developments that allowed the detection of genetic alterations of ctDNA in lung cancer. Furthermore, we explored clinical applications in patients with lung cancer including treatment efficiency monitoring, acquired therapy resistance mechanisms and prognosis value. |
| Publication | International Journal of Molecular Sciences |
| Volume | 18 |
| Issue | 2 |
| Date | Jan 29, 2017 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms18020264 |
| ISSN | 1422-0067 |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 28146051 PMCID: PMC5343800 |
| Tags | Biomarkers, Tumor, Biopsy, Diagnostic Tests, Routine, Disease Management, DNA, Neoplasm, first-last-corresponding, Genomics, High-Throughput Nucleotide Sequencing, Humans, lung cancer, Lung Neoplasms, molecular diagnosis, Neoplastic Cells, Circulating, Polymerase Chain Reaction, Precision Medicine, Prognosis, review, routine practice, targeted therapies, Tumor Burden |
| Date Added | 2019/09/13 - 11:56:02 |
| Date Modified | 2020/10/04 - 14:02:01 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
