| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Setting up a quantitative SPECT imaging network for a European multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project |
| Creator | Taprogge et al. |
| Author | Jan Taprogge |
| Author | Francesca Leek |
| Author | Tino Schurrat |
| Author | Johannes Tran-Gia |
| Author | Delphine Vallot |
| Author | Manuel Bardiès |
| Author | Uta Eberlein |
| Author | Michael Lassmann |
| Author | Susanne Schlögl |
| Author | Alex Vergara Gil |
| Author | Glenn D. Flux |
| Abstract | BACKGROUND: Differentiated thyroid cancer has been treated with radioiodine for almost 80?years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresolved. Multi-centre clinical studies are required to ensure recruitment of sufficient patients to achieve the statistical significance required to address these issues. Optimisation and standardisation of data acquisition and processing are necessary to ensure quantitative imaging and patient-specific dosimetry. MATERIAL AND METHODS: A European network of centres able to perform standardised quantitative imaging of radioiodine therapy of thyroid cancer patients was set-up within the EU consortium MEDIRAD. This network will support a concurrent series of clinical studies to determine accurately absorbed doses for thyroid cancer patients treated with radioiodine. Five SPECT(/CT) systems at four European centres were characterised with respect to their system volume sensitivity, recovery coefficients and dead time. RESULTS: System volume sensitivities of the Siemens Intevo systems (crystal thickness 3/8?) ranged from 62.1 to 73.5 cps/MBq. For a GE Discovery 670 (crystal thickness 5/8?) a system volume sensitivity of 92.2 cps/MBq was measured. Recovery coefficients measured on three Siemens Intevo systems show good agreement. For volumes larger than 10?ml, the maximum observed difference between recovery coefficients was found to be ± 0.02. Furthermore, dead-time coefficients measured on two Siemens Intevo systems agreed well with previously published dead-time values. CONCLUSIONS: Results presented here provide additional support for the proposal to use global calibration parameters for cameras of the same make and model. This could potentially facilitate the extension of the imaging network for further dosimetry-based studies. |
| Publication | EJNMMI physics |
| Volume | 7 |
| Issue | 1 |
| Pages | 61 |
| Date | 2020-10-08 |
| Journal Abbr | EJNMMI Phys |
| Language | eng |
| DOI | 10.1186/s40658-020-00332-9 |
| ISSN | 2197-7364 |
| Library Catalog | PubMed |
| Extra | Number: 1 PMID: 33030702 PMCID: PMC7544799 |
| Tags | Differentiated thyroid cancer, Dosimetry, Multi-centre trial, original, Radioiodine, Scientific |
| Date Added | 2023/11/23 - 12:44:33 |
| Date Modified | 2024/12/15 - 11:46:05 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
