| Added by | tchardes |
|---|---|
| Group name | EquipeELC |
| Item Type | Journal Article |
| Title | Latent TGF-? Activation Is a Hallmark of the Tenascin Family |
| Creator | Aubert et al. |
| Author | Alexandre Aubert |
| Author | Perrine Mercier-Gouy |
| Author | Stéphanie Aguero |
| Author | Laurent Berthier |
| Author | Sophie Liot |
| Author | Laura Prigent |
| Author | Lindsay B. Alcaraz |
| Author | Bernard Verrier |
| Author | Raphaël Terreux |
| Author | Catherine Moali |
| Author | Elise Lambert |
| Author | Ulrich Valcourt |
| Abstract | Transforming growth factor-? (TGF-?) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-? entities and their N-terminal pro-domains called latency-associated peptides (LAP). Extracellular activation of latent TGF-? within this complex is a crucial step in the regulation of TGF-? activity for tissue homeostasis and immune cell function. We previously showed that the matrix glycoprotein Tenascin-X (TN-X) interacted with the small latent TGF-? complex and triggered the activation of the latent cytokine into a bioactive TGF-?. This activation most likely occurs through a conformational change within the latent TGF-? complex and requires the C-terminal fibrinogen-like (FBG) domain of the glycoprotein. As the FBG-like domain is highly conserved among the Tenascin family members, we hypothesized that Tenascin-C (TN-C), Tenascin-R (TN-R) and Tenascin-W (TN-W) might share with TN-X the ability to regulate TGF-? bioavailability through their C-terminal domain. Here, we demonstrate that purified recombinant full-length Tenascins associate with the small latent TGF-? complex through their FBG-like domains. This association promotes activation of the latent cytokine and subsequent TGF-? cell responses in mammary epithelial cells, such as cytostasis and epithelial-to-mesenchymal transition (EMT). Considering the pleiotropic role of TGF-? in numerous physiological and pathological contexts, our data indicate a novel common function for the Tenascin family in the regulation of tissue homeostasis under healthy and pathological conditions. |
| Publication | Frontiers in Immunology |
| Volume | 12 |
| Pages | 613438 |
| Date | 2021 |
| Journal Abbr | Front Immunol |
| Language | eng |
| DOI | 10.3389/fimmu.2021.613438 |
| ISSN | 1664-3224 |
| Library Catalog | PubMed |
| Extra | PMID: 34054795 PMCID: PMC8155481 |
| Tags | immune cell modulation, latent TGF-? activation, review, tenascins, tissue homeostasis, transforming growth factor (TGF)-? |
| Date Added | 2021/06/04 - 10:37:24 |
| Date Modified | 2021/06/04 - 10:39:05 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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