| Added by | informatique.ircm |
|---|---|
| Group name | EQUIPEFC |
| Item Type | Journal Article |
| Title | TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells |
| Creator | Fasching et al. |
| Author | Liana Fasching |
| Author | Adamandia Kapopoulou |
| Author | Rohit Sachdeva |
| Author | Rebecca Petri |
| Author | Marie E. Jönsson |
| Author | Christian Männe |
| Author | Priscilla Turelli |
| Author | Patric Jern |
| Author | Florence Cammas |
| Author | Didier Trono |
| Author | Johan Jakobsson |
| Abstract | TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that derepression of ERVs influences transcriptional dynamics in NPCs through the activation of nearby genes and the expression of long noncoding RNAs. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. Our results warrant future studies on the role of ERVs in the healthy and diseased brain. |
| Publication | Cell Reports |
| Volume | 10 |
| Issue | 1 |
| Pages | 20-28 |
| Date | Jan 06, 2015 |
| Journal Abbr | Cell Rep |
| Language | eng |
| DOI | 10.1016/j.celrep.2014.12.004 |
| ISSN | 2211-1247 |
| Library Catalog | PubMed |
| Extra | PMID: 25543143 PMCID: PMC4434221 |
| Tags | Animals, DNA Methylation, Embryonic Stem Cells, Endogenous Retroviruses, Gene Expression Regulation, Developmental, Heterochromatin, Histones, Humans, Mice, Neurons, Nuclear Proteins, Repressor Proteins, Stem Cells, Transcription, Genetic, Tripartite Motif-Containing Protein 28 |
| Date Added | 2019/12/19 - 16:35:17 |
| Date Modified | 2019/12/19 - 16:35:17 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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